Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats
Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats
复制标题
DOI：
10.1080/09168451.2014.951025
复制
发表时间：
2015-01-02
影响因子：
1.6
通讯作者：
Kishida, Taro
中科院分区：
文献类型：
--
作者：
Kawabata, Fuminori;Mizushige, Takafumi;Kishida, Taro
在我们之前的研究中，鱼蛋白被证明可以通过骨骼肌肥大和增加基础能量消耗来降低大鼠的血脂和体脂积聚。在目前的研究中，我们研究了鱼蛋白摄入对不同骨骼肌纤维类型和肌肉代谢基因表达的精确影响。与酪蛋白饲料相比，鱼蛋白在喂养6周或8周后增加了快速抽动肌肉的重量，降低了肝脏甘油三酯和血糖水平。此外，鱼蛋白上调了肌肉中一种快速抽动肌型标记和一种葡萄糖转运蛋白的基因表达。这些结果表明，鱼蛋白可诱导快速肌肉肥大，而肌肉肥大增加基础能量消耗和增加肌肉葡萄糖摄取可降低肝脂和血糖水平。目前的结果还表明，摄取鱼类蛋白质会导致肌肉纤维类型从慢到快的转变。
In our previous study, fish protein was proven to reduce serum lipids and body fat accumulation by skeletal muscle hypertrophy and enhancing basal energy expenditure in rats. In the present study, we examined the precise effects of fish protein intake on different skeletal muscle fiber types and metabolic gene expression of the muscle. Fish protein increased fast-twitch muscle weight, reduced liver triglycerides and serum glucose levels, compared with the casein diet after 6 or 8weeks of feeding. Furthermore, fish protein upregulated the gene expressions of a fast-twitch muscle-type marker and a glucose transporter in the muscle. These results suggest that fish protein induces fast-muscle hypertrophy, and the enhancement of basal energy expenditure by muscle hypertrophy and the increase in muscle glucose uptake reduced liver lipids and serum glucose levels. The present results also imply that fish protein intake causes a slow-to-fast shift in muscle fiber type.