Does recent alcohol consumption reduce the risk of acute myocardial infarction and coronary death in regular drinkers?
Does recent alcohol consumption reduce the risk of acute myocardial infarction and coronary death in regular drinkers?
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经常饮酒的人近期饮酒是否会降低急性心肌梗塞和冠心病死亡的风险？
DOI：
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发表时间：
1992
影响因子：
5
通讯作者：
R. Beaglehole
中科院分区：
文献类型：
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作者：
R. Jackson;R. Scragg;R. Beaglehole
这项研究自 1986 年 3 月起在新西兰奥克兰进行，历时两年多，采用病例对照设计来调查以下假设：对于经常饮酒的人来说，酒精会在饮酒后 24 小时内急剧增加非致命性心肌梗塞和冠心病死亡的风险。非致命性心肌梗死分析包括从基于人群的冠心病监测计划中确定的 278 名男性和 60 名女性病例，以及从年龄和性别匹配的同一人群中随机选择的 458 名男性和 266 名女性对照。在冠心病死亡分析中，对来自同一监测项目的 172 名男性和 16 名女性冠心病死亡病例以及年龄和性别匹配的 294 名男性和 165 名女性的人口样本进行了检查。收集了病例冠状动脉事件发生前 24 小时内以及对照组中可比较的 24 小时内饮酒量的信息。研究对象均每月至少定期饮酒一次，年龄在 25 至 64 岁之间。对照组比病例更有可能在 24 小时内报告饮酒事件，无论是男性还是致命疾病。在控制了可能的混杂因素后，作者发现，与过去 24 小时内没有饮酒的参与者相比，饮酒者患致命和非致命冠心病的估计风险始终较低。男性非致命性心肌梗死的比值比为 0.75（95% 置信区间 0.62-0.90），女性冠心病死亡的比值比为 0.46（95% 置信区间 0.19-1.10）。 24 小时内喝一两杯、三四杯或四杯以上的人的估计急性风险没有明显差异。这些发现表明，与之前的推测相反，饮酒可能会大大降低冠心病的风险。
This study, conducted in Auckland, New Zealand, over 2 years from March 1986, used a case-control design to investigate the hypothesis that alcohol acutely increases the risk of both nonfatal myocardial infarction and coronary death in the 24 hours after drinking, among regular drinkers. The nonfatal myocardial infarction analyses included 278 male and 60 female cases identified from a population-based coronary heart disease surveillance program and 458 male and 266 female controls randomly selected from the same population matched by age and sex. In the coronary death analyses, 172 male and 16 female coronary death cases from the same surveillance program and a population-based sample of 294 males and 165 females who were age and sex matched were examined. Information on alcohol consumption in the 24 hours before the coronary event in cases and a comparable 24-hour period in controls was collected. Study subjects all drank alcohol regularly at least once per month and were aged 25-64 years. Controls were more likely than cases to report a drinking episode in the 24-hour period examined in both sexes and for fatal and nonfatal disease. After controlling for possible confounding, the authors found that drinkers had a consistently lower estimated risk of both fatal and nonfatal coronary heart disease than participants reporting no alcohol in the previous 24 hours. The odds ratios ranged from 0.75 (95% confidence interval 0.62-0.90) for nonfatal myocardial infarction in men to 0.46 (95% confidence interval 0.19-1.10) for coronary death in women. There were no clear differences in estimated acute risk among those who drank one or two drinks, three or four drinks, or more than four drinks in the 24-hour period. These findings suggest that, contrary to previous speculation, alcohol consumption may acutely reduce coronary heart disease risk.