Characterization and preliminary in vivo evaluation of a self-expandable hydrogel stent with anisotropic swelling behavior and endoscopic deliverability for use in biliary drainage
Characterization and preliminary in vivo evaluation of a self-expandable hydrogel stent with anisotropic swelling behavior and endoscopic deliverability for use in biliary drainage
复制标题
用于胆道引流的具有各向异性膨胀行为和内镜输送能力的自膨胀水凝胶支架的表征和初步体内评估
DOI：
10.1039/d2tb00104g
复制
发表时间：
2022
影响因子：
7
通讯作者：
Takao
中科院分区：
文献类型：
--
作者：
Nagakawa;Yoshiyasu; Fujita;Satoshi; Yunoki;Shunji; Tsuchiya;Takayoshi; Suye;Shin-ichiro; Kinoshita;Kenji; Sasaki;Motoki; Itoi;Takao
我们使用猪支架模型证明了由聚乙烯醇（PVA）水凝胶组成的新型自膨式胆道支架的潜力，该支架具有各向异性的溶胀行为和内窥镜体内输送能力。各向异性膨胀行为和内窥镜输送能力的机制（即，通过扫描电子显微镜（SEM）、小角X射线散射（SAXS）、水含量和溶胀比的评价以及三点弯曲测试来研究柔性）。使用猪支架模型的体内实验表明，管状PVA水凝胶可以有效地扩张胆道，而不会干扰胆汁流动。SEM和SAXS结果表明，拉伸干燥制备的PVA水凝胶沿拉伸轴沿着方向具有结构取向，导致各向异性溶胀。发现PVA水凝胶的含水量对于保持柔韧性以及内窥镜输送能力至关重要。总之，本研究证明了使用水凝胶支架作为自膨式胆道支架的新概念。
We demonstrate the potential of a novel self-expandable biliary stent comprised of poly(vinyl alcohol) (PVA) hydrogel with anisotropic swelling behavior and endoscopic deliverability in vivo, using a porcine stent model. The mechanism underlying the anisotropic swelling behavior and endoscopic deliverability (i.e., flexibility) was investigated by scanning electron microscopy (SEM), small-angle X-ray scattering (SAXS), evaluation of the water content and swelling ratio, and three-point bending tests. The in vivo experiment using a porcine stent model indicated that the tube-shaped PVA hydrogel could effectively expand the biliary tract, without disturbing bile flow. SEM and SAXS showed that PVA hydrogels prepared by drying under extension showed structural orientation along the extension axis, leading to anisotropic swelling. The water content of the PVA hydrogel was found to be crucial for maintaining flexibility as well as endoscopic deliverability. In conclusion, this study demonstrated the novel concept of using a hydrogel stent as a self-expandable biliary stent.