Noise-induced spiral waves in astrocyte syncytia show evidence of self-organized criticality
Noise-induced spiral waves in astrocyte syncytia show evidence of self-organized criticality
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DOI：
10.1152/jn.1998.79.2.1098
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发表时间：
1998-02-01
影响因子：
2.5
通讯作者：
Moss, F
中科院分区：
文献类型：
--
作者：
Jung, P;Cornell-Bell, A;Moss, F
在培养的神经胶质细胞网络中观察到长距离(几厘米)、长时间(数秒)、螺旋状的钙离子化学波(Ca2+)，以获得正常浓度的神经递质红藻氨酸。描述了一种定量测量波的时空大小的新方法。这一措施导致了波浪大小的幂函数分布，这意味着产生波浪的过程没有首选的空间或时间(大小或生命)尺度。这一幂定律是自组织批判现象的一个标志，这是在许多科学领域中发现的一类行为。神经网络的生理学结果得到了由噪声、交流阈值元件组成的简单网络的数值模拟的完全支持。相比之下，从人类癫痫灶培养的星形胶质细胞中观察到的波形表现出根本不同的行为。网络的背景随机活动或“噪声”由红藻氨酸浓度控制。平均成核率受网络噪声的影响。然而，在我们的实验精度内，在测试的噪声强度范围内，幂定律分布是不变的。这些观察结果表明，在健康的脊椎动物中枢神经系统中，由网络噪声介导的空间和时间上的相干钙波可能在长距离和长时间产生相关的神经活动(波)方面发挥重要作用。
Long range (a few centimeters), long lived (many seconds), spiral chemical waves of calcium ions (Ca2+) are observed in cultured networks of glial cells for normal concentrations of the neurotransmitter kainate. A new method for quantitatively measuring the spatiotemporal size of the waves is described. This measure results in a power law distribution of wave sizes, meaning that the process that creates the waves has no preferred spatial or temporal (size or lifetime) scale. This power law is one signature of self-organized critical phenomena, a class of behaviors found in many areas of science. The physiological results for glial networks are fully supported by numerical simulations of a simple network of noisy, communicating threshold elements. By contrast, waves observed in astrocytes cultured from human epileptic foci exhibited radically different behavior. The background random activity, or "noise", of the network is controlled by the kainate concentration. The mean rate of wave nucleation is mediated by the network noise. However, the power law distribution is invariant, within our experimental precision, over the range of noise intensities tested. These observations indicate that spatially and temporally coherent Ca2+ waves, mediated by network noise may play and important role in generating correlated neural activity (waves) over long distances and times in the healthy vertebrate central nervous system.