IMPAIRED NONMOTOR LEARNING AND ERROR-DETECTION ASSOCIATED WITH CEREBELLAR DAMAGE - A SINGLE CASE-STUDY
IMPAIRED NONMOTOR LEARNING AND ERROR-DETECTION ASSOCIATED WITH CEREBELLAR DAMAGE - A SINGLE CASE-STUDY
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DOI：
10.1093/brain/115.1.155
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发表时间：
1992-02-01
期刊：
影响因子：
14.5
通讯作者：
RAICHLE, ME
中科院分区：
文献类型：
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作者：
FIEZ, JA;PETERSEN, SE;RAICHLE, ME
此前对正常人进行的一项正电子发射断层扫描(PET)研究表明，小脑对语言处理有重要的非运动性贡献。从产生右侧小脑PET激活的任务开始，我们研究了一名49岁的男性(RCL)右侧小脑损伤，在涉及复杂的非运动加工的各种任务中。尽管RCL在记忆力、智力、额叶功能和语言技能的标准测试中表现出色，但他在两个方面存在严重缺陷：(1)与实践相关的学习；(2)错误检测。考虑到小脑对运动任务的贡献，结果表明，小脑执行的一些功能可能超出了纯粹的运动域。
A previously conducted positron emission tomography (PET) study of normal humans suggested that the cerebellum makes important non-motor contributions to language processing. Beginning with the task which produced right cerebellar PET activation, we studied a 49-yr-old male (RCl) with right cerebellar damage on a variety of tasks involving complex non-motor processing. Whereas RCl's performance on standard tests of memory, intelligence, 'frontal function' and language skills was excellent, he had profound deficits in two areas: (1) practice-related learning; (2) detection of errors. Considered in relation to cerebellar contributions to motor tasks, the results suggest some functions performed by the cerebellum may be generalized beyond a purely motor domain.