Quantification of Wave Reflection in the Human Umbilical Artery From Asynchronous Doppler Ultrasound Measurements.
Quantification of Wave Reflection in the Human Umbilical Artery From Asynchronous Doppler Ultrasound Measurements.
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DOI：
10.1109/tmi.2020.3004511
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发表时间：
2020-11
影响因子：
10.6
通讯作者：
Macgowan CK
中科院分区：
文献类型：
--
作者：
Stortz G;Cahill LS;Chandran AR;Baschat A;Sled JG;Macgowan CK
脐动脉搏动性升高是一种广泛使用的胎盘病理学生物标志物，可导致宫内生长受限，严重时可导致死胎。已经假设胎盘病理通过改变源自胎儿心脏的脉搏压力波从胎盘脉管系统反射以干扰入射波的程度来改变脐动脉搏动性。在这里，我们提出了一种方法，用于估计反射的脉搏波在人类胎儿的脐动脉使用异步采集多普勒超声测量从脐带的两端。该方法假设波沿动脉沿着的非色散和无损耗传播，并将反射过程建模为具有参数化脉冲响应的线性系统。通过约束优化从测量的多普勒波形确定模型参数。从142名怀孕志愿者中获得速度波形，其中123名至少在一条脐动脉中符合数据质量标准。反射模型与分析的212条动脉中的183条动脉的测量波形一致。通过将其应用于模拟数据集并将解决方案与地面实况进行比较，验证了分析方法。利用临床超声典型的测量噪声水平，准确地确定描述反射波的参数。
Elevated umbilical artery pulsatility is a widely used biomarker for placental pathology leading to intrauterine growth restriction and, in severe cases, still-birth. It has been hypothesized that placental pathology modifies umbilical artery pulsatility by altering the degree to which the pulse pressure wave, which originates from the fetal heart, is reflected from the placental vasculature to interfere with the incident wave. Here we present a method for estimating the reflected pulse wave in the umbilical artery of human fetuses using asynchronously acquired Doppler ultrasound measurements from the two ends of the umbilical cord. This approach assumes non-dispersive and loss-less propagation of the waves along the artery and models the reflection process as a linear system with a parameterized impulse response. Model parameters are determined from the measured Doppler waveforms by constrained optimization. Velocity waveforms were obtained from 142 pregnant volunteers where 123 met data quality criteria in at least one umbilical artery. The reflection model was consistent with the measured waveforms in 183 of 212 arteries that were analyzed. The analysis method was validated by applying it to simulated datasets and comparing solutions to ground-truth. With measurement noise levels typical of clinical ultrasound, parameters describing the reflected wave were accurately determined.