CENTRAL ADMINISTRATION OF CORTICOTROPIN RELEASING-FACTOR ALTERS RAT PUP ISOLATION CALLS
CENTRAL ADMINISTRATION OF CORTICOTROPIN RELEASING-FACTOR ALTERS RAT PUP ISOLATION CALLS
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DOI：
10.1016/0091-3057(89)90233-5
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发表时间：
1989-01-01
影响因子：
3.6
通讯作者：
HARBAUGH, CR
中科院分区：
文献类型：
--
作者：
INSEL, TR;HARBAUGH, CR
当幼鼠处于社会隔离状态时，它们会发出超声波发声，这被认为是表示痛苦的信号。本研究探讨脑室注射促肾上腺皮质激素释放因子(CRF)对超声隔离叫声产生的影响。在2分钟基线隔离试验后，给5-6日龄大鼠脑室注射CRF或CRF拮抗剂α-螺旋CRF(9-41)。30分钟后，CRF(0.1和0.01ug)组的呼叫数显著减少，CRF拮抗剂(1.0ug)组的呼叫数增加。这些效应不能用服用多肽后运动活性、体温调节或血浆糖皮质激素水平的变化来解释。外周给药CRF(1.0和10.0微克)不改变隔离呼叫的数量。
Rat pups, when socially isolated, emit ultrasonic vocalizations which are believed to indicate distress. This study investigated the effect of intracerebroventricular (ICV) administration of corticotropin releasing factor (CRF) on the production of ultrasonic isolation calls. Following a 2-minute baseline isolation test, rat pups (5-6 days old) were injected ICV with CRF or the CRF antagonist, .alpha.-helical CRF (9-41). Thirty minutes later, calls were significantly decreased following CRF (0.1 and 0.01 .mu.g) and increased following the CRF antagonist (1.0 .mu.g). These effects were not explained by changes in locomotor activity, thermoregulation, or plasma glucocorticoid levels following peptide administration. Peripheral administration of CRF (1.0 and 10.0 .mu.g) did not alter the number of isolation calls.