Olfactory bulb transplantation into the olfactory bulb of neonatal rats: a WGA-HRP study.
Olfactory bulb transplantation into the olfactory bulb of neonatal rats: a WGA-HRP study.
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将嗅球移植到新生大鼠的嗅球中：一项 WGA-HRP 研究。
DOI：
10.1016/0006-8993(92)91338-f
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Monti-Graziadei,AG
中科院分区：
文献类型：
--
作者：
Zigova,T;Graziadei,PP;Monti-Graziadei,AG
在新生大鼠（P1-P5）单侧嗅球切除术后，将放射自显影预标记的E15和E17胚胎嗅球移植到切除的组织中。2-7个月后，动物接受小麦胚芽凝集素-辣根过氧化物酶（WGA-HRP）注射到梨状皮质。20只动物中的9只显示放射自显影标记的神经元中的WGA-HRP阳性神经元，从而提供证据表明来自同伦移植的嗅球的输出神经元的轴突与宿主梨状皮质重新连接。
After unilateral bulbectomy in neonatal (P1–P5) rats, autoradiographically prelabeled presumptive olfactory bulbs from E15 and E17 embryos were transplanted in place of the removed tissue. After 2–7 months, the animals received injections of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) into the piriform cortex. Nine of the twenty animals revealed WGA-HRP-positive neurons among neurons autoradiographically labeled, providing thus evidence that the axons of the output neurons from the homotopically transplanted olfactory bulb reconnect with the host piriform cortex.