An Efficient One-Pot Strategy for the Synthesis of Triazole-Fused 1,4-Benzodiazepinones from N-Substituted 2-Azidobenzamides
An Efficient One-Pot Strategy for the Synthesis of Triazole-Fused 1,4-Benzodiazepinones from N-Substituted 2-Azidobenzamides
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DOI：
10.1055/s-0033-1339346
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发表时间：
2013-09-17
影响因子：
2.6
通讯作者：
Ganai, Sintu
中科院分区：
文献类型：
--
作者：
Majumdar, K. C.;Ganai, Sintu
报道了一种无催化剂、一锅法合成1，2，3-三唑稠合的1，4-苯并二氮杂卓衍生物的方法。通过N-烷基化，然后进行1，3-偶极环加成，以良好至优异的产率形成产物。
A catalyst-free, one-pot strategy for the synthesis of 1,2,3-triazole-fused 1,4-benzodiazepinone derivatives from N-substituted 2-azidobenzamides and propargyl bromide, in the presence of a base, is reported. The products are formed in good to excellent yields via N-alkylation followed by a 1,3-dipolar cycloaddition.