Sry-negative XX true hermaphroditism in a roe deer
Sry-negative XX true hermaphroditism in a roe deer
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DOI：
10.1016/j.anireprosci.2008.04.018
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发表时间：
2009-05-01
影响因子：
2.2
通讯作者：
Royo, L. J.
中科院分区：
文献类型：
--
作者：
Pajares, G.;Balseiro, A.;Royo, L. J.
在西班牙北部（阿斯图里亚斯）的一次狩猎中，一只两岁大的梅花鹿被捕获。在体检中，该个体呈现出发育良好的裸露鹿角，但令人惊讶的是，它的外生殖器是雌性的。为了解释观察到的表型，进行了几项解剖学、组织学和遗传学分析。尸检证明卵巢样结构与卵泡的表面上;睾丸的组织学分析证明阳性免疫标记睾丸间质细胞中的睾酮;遗传分析表明，个体的性别是一致的女性个体。PCR分析未能检测到SRY序列，没有检测到PIS缺失，这是负责山羊XX性逆转。根据其推测的正常雌性性染色体核型（XX）和存在两个功能性的腹部双侧睾丸和卵巢，最终诊断为患有XX两性畸形综合征。然而，与许多其他病例一样，无法确定该两性畸形病例发生的具体原因。(C)2008 Elsevier B. V.保留所有权利。
A two-year-old roe deer was brought down in the course of a hunt in the north of Spain (Asturias). On physical examination the individual presented well-developed bared antlers, but surprisingly a female external genitalia. Several anatomical, histological and genetic analyses were performed in order to explain the observed phenotype. Necropsy evidenced ovary-like structures with follicles on the surface; histological analyses of testes evidenced positive immunolabel against testosterone in Leydig cells; genetic analyses showed that the sex of the individual was consistent with a female individual. PCR analysis failed to detect SRY sequences; no PIS deletion, which is responsible for XX sex-reversal in goats, was detected. On the basis of its presumptive normal female sexual karyotype (XX) and the presence of two functional abdominal bilateral testes and ovaries, the roe deer was finally diagnosed as possessing an XX hermaphroditism syndrome. However, as in many other cases, the specific reason for the occurrence of this case of hermaphroditism could not be determined. (C) 2008 Elsevier B.V. All rights reserved.