In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease
In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease
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DOI：
10.3233/jad-160316
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发表时间：
2017-01-01
影响因子：
4
通讯作者：
Drzezga, Alexander
中科院分区：
文献类型：
--
作者：
Dronse, Julian;Fliessbach, Klaus;Drzezga, Alexander
阿尔茨海默病的临床异质性并没有反映在相当弥漫的淀粉样β蛋白的皮质沉积上。我们使用新的多模式PET成像技术评估了临床症状、活体tau病理、淀粉样蛋白分布和阿尔茨海默病变异体的低代谢之间的关系。TAU病理主要观察到与临床症状相关的脑区，并与低代谢区域重叠。相反，淀粉样β蛋白沉积广泛分布于整个大脑皮层。因此，tau PET成像可以作为体内神经元损伤定位的一个有价值的生物标志物，并可能有助于验证阿尔茨海默病的非典型亚型。
The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-beta. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-beta deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.