Mechanisms of vertebrate segmentation.
Mechanisms of vertebrate segmentation.
复制标题
脊椎动物的分割机制。
作者：
R. Keynes;C. Stern
所有高等生物在发育过程中都具有某些节段组织，这大概不是巧合。分割似乎是一个重要的发展战略，建立和多样化不同的身体区域。它可以在许多层面上进行研究，从分子和基因组，到细胞及其相互作用，再到形态发生和全身模式;没有令人信服的理由认为任何一个层面的研究将比任何其他层面的研究更能揭示问题。事实上，脊椎动物分割的研究为这种哲学提供了一个特别好的例子。经典和分子遗传学分析在果蝇发育中的应用（Akam，1987年综述）已经产生了大量关于基因的信息，这些基因在果蝇体节模式的发育中起作用。从这一分析中直接产生的希望是，将类似的方法应用于脊椎动物的发育，以脊椎动物基因组中同源框的发现为例，将同样成功。但是，脊椎动物分割基因的识别是否会使我们对分割过程的理解更加完整呢？我们认为没有，我们在这次审查中的主要目的是确定和讨论人们可以在不同层次上处理所涉及的重大事件。
That all higher organisms possess some segmental organization during their development is presumably no coincidence. Segmentation appears to be an important developmental strategy with which to build and diversify different body regions. It can be studied at many levels, ranging from molecule and genome, through cells and their interactions, to morphogenesis and whole body pattern; and there is no compelling reason for thinking that the study of any one level will prove more revealing than that of any other. The study of vertebrate segmentation in fact provides a particularly good example of this philosophy. The application of classical and molecular genetic analysis to Drosophila development (reviewed by Akam, 1987) has yielded a large amount of information about the genes that play a role in the development of segmental patterns in this organism. Springing directly from this analysis comes the hope that similar methods applied to vertebrate development, exemplified by the discovery of the homeobox in the vertebrate genome, will be just as successful. But will the identification of vertebrate segmentation genes complete our understanding of the segmentation process? We believe not, and our chief purpose in this review is to identify and discuss the variety of different levels at which one can approach the major events involved.
光学显微镜观察鸡胚胎形态发生运动过程中肌动蛋白的分布。
DOI：
--
发表时间：
1983
期刊：
Journal of embryology and experimental morphology
影响因子：
--
作者：
Ostrovsky,D;Sanger,JW;Lash,JW
通讯作者：
Lash,JW
影响因子：
56.9
作者：
RUOSLAHTI, E;PIERSCHBACHER, MD
通讯作者：
PIERSCHBACHER, MD