Improved mechanism for capturing muscle power for circulatory support
Improved mechanism for capturing muscle power for circulatory support
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DOI：
10.1111/j.1525-1594.2005.29108.x
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发表时间：
2005-09-01
影响因子：
2.4
通讯作者：
Magovern, JA
中科院分区：
文献类型：
--
作者：
Trumble, DR;Melvin, DB;Magovern, JA
尽管现在人们知道，经过训练的骨骼肌可以产生足够的稳态功率来提供显着的循环支持，但目前还没有办法利用这种内源能源来帮助衰竭的心脏。为此，我们构建了植入式肌肉能量转换器（MEC），并改进了其功能，以优化耐用性、解剖学贴合性和机械效率。台架测试表明，MEC 传输损失平均不到总输入功的 10%，并且大约 85% 的人力成功地转移到泵的工作流体中。犬类植入物试验的结果证实了良好的生物相容性，并证明背阔肌的收缩功（在一只狗中测量为 290 mJ/冲程）可以在体内以符合心脏辅助要求的水平传输。这些发现表明肌肉驱动的心脏辅助装置是可行的，并且有必要进一步开发这项技术。
Although it is now understood that trained skeletal muscle can generate enough steady-state power to provide significant circulatory support, there are currently no means by which to tap this endogenous energy source to aid the failing heart. To that end, an implantable muscle energy converter (MEC) has been constructed and its function has been improved to optimize durability, anatomic fit, and mechanical efficiency. Bench tests show that MEC transmission losses average less than 10% of total work input and that about 85% of this muscle power is successfully transferred to the working fluid of the pump. Results from canine implant trials confirm excellent biocompatibility and demonstrate that contractile work of the latissimus dorsi muscle-measured to 290 mJ/stroke in one dog-can be transmitted within the body at levels consistent with cardiac assist requirements. These findings suggest that muscle-powered cardiac assist devices are feasible and that efforts to further develop this technology are warranted.