Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
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DOI：
10.1016/s0168-8278(00)80242-1
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发表时间：
2000-05-01
影响因子：
25.7
通讯作者：
Bode, C
中科院分区：
文献类型：
--
作者：
Parlesak, A;Schäfer, C;Bode, C
背景/目的：目前还没有关于酒精滥用对大分子(M-r>；1200)通过人体肠道粘膜移位的影响的信息。本研究旨在测定慢性酒精滥用和轻度至晚期肝病患者肠道对大分子物质的通透性，以及血浆内毒素的浓度，因为这些化合物来源于肠道菌群，可能与酒精性肝病(ALD)的发生有关。方法：测定54例酒精性肝病患者(其中19例为肝硬变患者)对聚乙二醇M-R400、M-R1500、M-R4000和M-R10000的通透性和血浆内毒素浓度。结果：与健康对照组相比，ALD患者对聚乙二醇M-R400的通透性无明显变化，而尿中聚乙二醇M-R1500和M-R4000的通透性恢复到正常对照组的两倍(P
Background/Aims: No information is yet available about the influence of alcohol abuse on the translocation of larger molecules (M-r> 1200) through the intestinal mucosa in man. The present study aimed to determine the intestinal permeability to macromolecules in patients with chronic alcohol abuse and mild to more advanced stages of liver disease, and to measure the concentration of endotoxins in the plasma, as these compounds derive from the intestinal flora and are suspected to contribute to the development of alcoholic liver disease (ALD),Methods: The permeability to polyethylene glycol M-r 400, M-r 1500, M-r 4000, and M-r 10 000 and endotoxin plasma concentrations were measured in 54 patients with alcoholic liver disease, 19 of them with cirrhosis, and in 30 non-alcoholic healthy controls.Results: Permeability to polyethylene glycol M-r 400 was found to be unchanged in patients with ALD in comparison to healthy controls, whereas polyethylene glycol M-r 1500 and M-r 4000 were recovered in about twice as high concentrations in the urine of ALD patients (p