Composition and control of secretions from tracheal bronchial submucosal glands
Composition and control of secretions from tracheal bronchial submucosal glands
复制标题
气管支气管粘膜下腺分泌物的组成和控制
作者：
P. Quinton
气管支气管粘膜下腺（TBS）被认为提供了很大一部分呼吸道液体（RTF）1，这对清洁肺部气道至关重要。在清洁过程中，气管支气管树中的纤毛不断将RTF扫过，带着杂物，排出肺外。但RTF的物理化学性质异常可能会损害这种清除，导致液体停滞、感染和气道阻塞。不幸的是，由于TBS腺体体积小，难以接近，难以收集其未受污染的分泌物，因此对其生理学知之甚少。我们已经开发了收集和分析猫体外单个TBS腺体分泌物的方法，我们在这里描述了这些腺体分泌的液体的组成和控制。我们发现分泌液的组成与细胞外液非常相似，分泌流量主要受α-肾上腺素能和胆碱能激动剂的影响。鉴于致死性遗传疾病囊性纤维化（CF）2中众所周知的外源性病变，我们相信这些发现对该疾病气道的病理改变具有启示意义。
TRACHEAL bronchial submucosal (TBS) glands are thought to supply a significant fraction of respiratory tract fluid (RTF)1, which is critically important in cleaning the airways of the lung. In the cleaning process, cilia in the tracheal bronchial tree continuously sweep the RTF, with debris, out of the lung. But abnormalities in the physicochemical properties of the RTF may impair this clearance, resulting in fluid stagnation, infection and obstruction of the airways. Unfortunately, because of the small size and inaccessibility of TBS glands and the difficulty in collecting their uncontaminated secretions, little is known about their physiology. We have developed methods for collecting and analysing secretions from single TBS glands of the cat in vitro, and we describe here the composition and control of the fluid secreted by these glands. We have found that the composition of the secreted fluids is very similar to that of the extracellular fluid and that secretion flow rates are influenced predominantly by α-adrenergic and cholinergic agonists. In view of the well known exocrinopathy in the lethal genetic disease cystic fibrosis (CF)2, we believe these findings to have implications for pathological changes in the airways in this disease.