Sintered carbonate apatites as bioresorbable bone substitutes
Sintered carbonate apatites as bioresorbable bone substitutes
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DOI：
10.1002/(sici)1097-4636(19980315)39:4
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发表时间：
1998-03-15
期刊：
影响因子：
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通讯作者：
Iwayama, Y
中科院分区：
文献类型：
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作者：
Doi, Y;Shibutani, T;Iwayama, Y
研究了烧结后的碳酸盐磷灰石在37℃下10 mM/L pH调至5.0的醋酸溶液中的溶解行为，并与烧结后的羟基磷灰石和骨磷灰石进行了比较，目的是建立磷灰石生物材料在体外的理化溶解与体内破骨细胞吸收能力之间的一些相似性。烧结的碳酸盐磷灰石和骨磷灰石均有一定程度的溶解。它们的溶液组成几乎以相同的方式变化，直到反应结束。碳酸盐磷灰石30 s烧结后的溶液组成与3.8 d羟基磷灰石烧结后的溶液组成过饱和度相当，表明前者比后者更容易溶解。从1日龄新生兔长骨中获得的破骨细胞吸收骨和烧结碳酸盐磷灰石，但不吸收烧结羟基磷灰石。这些发现表明，烧结的碳酸盐磷灰石具有与骨相比更有利的特性，特别是其对酸性介质的反应性，将有助于作为生物可吸收的骨替代品。(C) 1998 John Wiley & Sons公司
The dissolution behavior of sintered carbonate apatite was investigated in a 10 mM/L acetic acid solution adjusted to pH 5.0 at 37 degrees C, and compared to that of sintered hydroxyapatite and bone apatite for the purpose of establishing some similarities between the physicochemical dissolution of apatite biomaterials in vitro and their ability to be resorbed by osteoclasts in vivo. Both the sintered carbonate apatite and the bone apatite dissolved to an appreciable extent. Their solution compositions chanced in an almost identical manner until toward the end of the reaction. The solution compositions for sintered carbonate apatite at 30 s was comparable with that for sintered hydroxyapatite at 3.8 days with respect to the degree of supersaturation, indicating that the former specimen is much more soluble than the latter specimen. Osteoclasts which were obtained from the long bones of 1-day-old neonatal rabbits resorbed bone and sintered carbonate apatite, but not sintered hydroxyapatite. These findings suggest that sintered carbonate apatites, which have characteristics that can be favorably compared with those of bone, especially with respect to its reactivity to acid media, would be useful as bioresorbable bone substitutes. (C) 1998 John Wiley & Sons, Inc.