Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area
Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area
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DOI：
10.1152/ajpregu.00574.2009
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发表时间：
2010-01-01
影响因子：
2.8
通讯作者：
DiMicco, Joseph A.
中科院分区：
文献类型：
--
作者：
Hunt, Joseph L.;Zaretsky, Dmitry V.;DiMicco, Joseph A.
亨特JL，扎雷茨基DV，萨卡尔·S，迪米科·J·A。背内侧下丘脑调节从视前内侧区域诱发的自主神经、神经内分泌和运动反应。Am J Physiol Regul Integr Comp Physiol 298：R130-R140,2010.2009年11月18日首次出版；DOI：10.1152/ajpregu.00574.2009。-先前的研究表明，麻醉大鼠从视前区诱发的交感反应需要激活下丘脑背内侧的神经元。去抑制清醒大鼠下丘脑背内侧的神经元，可产生类似于视前内侧区微量注射GABA(A)受体激动剂和神经元抑制剂--蝇草醇所引起的生理和行为变化。我们通过评估双侧DMH内微量注射蝇草酚对这些变化的影响，检验了所有从内侧视前区诱发的这些效应都是通过下丘脑背内侧区神经元介导的假设。在向下丘脑背内侧注射车辆后，向视前内侧区注射蝇草酚引起心率、动脉压、体温、血浆ACTH和运动活动显著增加，并增加了下丘脑室旁核c-Fos的表达，该区域控制ACTH从腺垂体释放。预先双侧下丘脑背内侧微量注射蝇草酚可使基线心率和体温适度降低，但完全消除了视前内侧区引起的所有变化。在下丘脑背内侧前方微量注射蝇草酚对内侧视前区诱发的自主神经和神经内分泌变化没有影响。因此，下丘脑背内侧的神经元活动介导了由内侧视前区引起的一系列不同的生理和行为反应，表明后者是下丘脑背内侧关键神经元抑制音的重要来源。
Hunt JL, Zaretsky DV, Sarkar S, DiMicco JA. Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area. Am J Physiol Regul Integr Comp Physiol 298: R130-R140, 2010. First published November 18, 2009; doi:10.1152/ajpregu.00574.2009.-Previous studies suggest that sympathetic responses evoked from the preoptic area in anesthetized rats require activation of neurons in the dorsomedial hypothalamus. Disinhibition of neurons in the dorsomedial hypothalamus in conscious rats produces physiological and behavioral changes resembling those evoked by microinjection of muscimol, a GABA(A) receptor agonist and neuronal inhibitor, into the medial preoptic area. We tested the hypothesis that all of these effects evoked from the medial preoptic area are mediated through neurons in the dorsomedial hypothalamus by assessing the effect of bilateral microinjection of muscimol into the DMH on these changes. After injection of vehicle into the dorsomedial hypothalamus, injection of muscimol into the medial preoptic area elicited marked increases in heart rate, arterial pressure, body temperature, plasma ACTH, and locomotor activity and also increased c-Fos expression in the hypothalamic paraventricular nucleus, a region known to control the release of ACTH from the adenohypophysis. Prior bilateral microinjection of muscimol into the dorsomedial hypothalamus produced a modest depression of baseline heart rate and body temperature but completely abolished all changes evoked from the medial preoptic area. Microinjection of muscimol just anterior to the dorsomedial hypothalamus had no effect on autonomic and neuroendocrine changes evoked from the medial preoptic area. Thus, activity of neurons in the dorsomedial hypothalamus mediates a diverse array of physiological and behavioral responses elicited from the medial preoptic area, suggesting that the latter region represents an important source of inhibitory tone to key neurons in the dorsomedial hypothalamus.