Antibiotics, birth mode, and diet shape microbiome maturation during early life.
Antibiotics, birth mode, and diet shape microbiome maturation during early life.
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DOI：
10.1126/scitranslmed.aad7121
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发表时间：
2016-06-15
影响因子：
17.1
通讯作者：
Blaser MJ
中科院分区：
文献类型：
--
作者：
Bokulich NA;Chung J;Battaglia T;Henderson N;Jay M;Li H;D Lieber A;Wu F;Perez-Perez GI;Chen Y;Schweizer W;Zheng X;Contreras M;Dominguez-Bello MG;Blaser MJ
幼儿期是微生物群和宿主形成和发育的关键阶段。早期的抗生素暴露、剖腹产和配方奶喂养可能会扰乱微生物群的建立，并对以后的健康产生不利影响。我们描述了43名美国婴儿出生后头两年的微生物发育情况，并确定了与抗生素暴露、剖腹产和饮食有关的多种障碍。抗生素延缓了微生物群的发育，并抑制了梭状芽孢杆菌，包括乳杆菌科细菌。剖腹产导致类杆菌种群枯竭，改变了母体细菌的建立。配方奶喂养与年龄相关的多样性偏差有关。这些发现说明了早期生命微生物群发育的复杂性，以及可能导致肥胖、哮喘和其他疾病的抗生素使用、剖腹产和配方奶喂养的微生物群失调。抗生素、剖腹产和婴儿配方奶粉改变了儿童头两年的微生物获取和继承模式。
Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first two years of life in a cohort of 43 US infants, and identify multiple disturbances associated with antibiotic exposures, cesarean section, and diet. Antibiotics delayed microbiome development and suppressed Clostridiales, including Lachnospiraceae. Cesarean section led to depleted Bacteroidetes populations, altering establishment of maternal bacteria. Formula-feeding was associated with age-dependent diversity deviations. These findings illustrate the complexity of early-life microbiome development, and microbiota disturbances with antibiotic use, cesarean section, and formula feeding that may contribute to obesity, asthma, and other disorders. Antibiotics, cesarean section, and infant formula alter patterns of microbial acquisition and succession during the first 2 years of childhood.