Subthalamic nucleus stimulation in Parkinson's disease:: Correlation of active electrode contacts with intraoperative microrecordings
Subthalamic nucleus stimulation in Parkinson's disease:: Correlation of active electrode contacts with intraoperative microrecordings
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DOI：
10.1159/000075158
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发表时间：
2003-01-01
影响因子：
1.7
通讯作者：
Mehdorn, HM
中科院分区：
文献类型：
--
作者：
Hamel, W;Fietzek, U;Mehdorn, HM
背景/目的：刺激丘脑底核（subthalamic nucleus，简称STN）的最有效部位仍不清楚。主动接触的位置相对于背侧缘的的骨关节被确定。方法：对25例患者（n = 49）进行微记录和沿着5个轨迹的微刺激，然后植入电极（n = 49）。主动接触的立体定位位置被确定，并与显微记录使用算法直接三维比较（n = 37）。结果如下：大多数活动接触被检测到在+/-1.0 mm范围内的背侧边缘的定义由显微记录（32.4%）或更远的背侧在丘脑底区（37.8%），只有29.7%是本地化到适当的背侧。这与这三组中活动触点的平均立体定向坐标一致。结论：我们的数据表明，背侧缘区的小脑扁桃体是最有效的目标。除了背外侧投射（感觉运动部分），这可能包括来自/到背外侧投射、不确定性投射和Forel视野中的离苍白球投射。版权所有（C）2003 S. Karger AG，巴塞尔。
Background/Aims: The most effective site for subthalamic nucleus (STN) stimulation has remained unclear. The position of active contacts relative to the dorsal margin of the STN was determined. Methods: Electrodes (n = 49) were implanted following STN mapping by microrecording and microstimulation along five tracks ( n = 25 patients). The stereotactic position of active contacts was determined and correlated with microrecordings using an algorithm for direct three-dimensional comparisons ( n = 37). Results: Most active contacts were detected within +/-1.0 mm from the dorsal margin of the STN as defined by microrecording (32.4%) or farther dorsal in the subthalamic area (37.8%), and only 29.7% were localized to the STN proper. This was consistent with the average stereotactic coordinates of the active contacts in these three groups. Conclusion: Our data suggest that the dorsal border area of the STN is the most effective target. Besides the dorsolateral STN ( sensorimotor part) this may include projections from/ to STN, the zona incerta, and pallidofugal projections in the fields of Forel. Copyright (C) 2003 S. Karger AG, Basel.