Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?
Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?
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DOI：
10.7150/thno.7193
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发表时间：
2013-12-11
期刊：
影响因子：
12.4
通讯作者：
Choyke PL
中科院分区：
文献类型：
--
作者：
Kobayashi H;Watanabe R;Choyke PL
与低分子药物相比，纳米治疗剂具有几个优点，如更大的载药量，能够保护有效载荷直到释放，由于多价性而具有更高的靶向性，以及有机会控制/持续释放。然而，纳米药物进入肿瘤组织是有问题的，因为它主要依赖于增强的渗透性和滞留(EPR)效应，这取决于肿瘤血管的渗漏性质和纳米药物的长时间循环，允许缓慢但不均匀地在肿瘤床中积累。纳米药物的释放依赖于几个影响EPR效应的因素：1.肿瘤的局部血流，2.肿瘤血管的通透性，3.血管周围肿瘤细胞和细胞外基质的结构性屏障，4.肿瘤内的压力。在这篇综述中，将描述这些因素，并对提高纳米制剂输送能力的方法进行综述。
Nano-sized therapeutic agents have several advantages over low molecular weight agents such as a larger loading capacity, the ability to protect the payload until delivery, more specific targeting due to multivalency and the opportunity for controlled/sustained release. However, the delivery of nano-sized agents into cancer tissue is problematic because it mostly relies on the enhanced permeability and retention (EPR) effect that depends on the leaky nature of the tumor vasculature and the prolonged circulation of nano-sized agents, allowing slow but uneven accumulation in the tumor bed. Delivery of nano-sized agents is dependent on several factors that influence the EPR effect; 1. Regional blood flow to the tumor, 2. Permeability of the tumor vasculature, 3. Structural barriers imposed by perivascular tumor cells and extracellular matrix, 4. Intratumoral pressure. In this review, these factors will be described and methods to enhance nano-agent delivery will be reviewed.
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影响因子：
17.4
作者：
Gormley AJ;Larson N;Sadekar S;Robinson R;Ray A;Ghandehari H
通讯作者：
Ghandehari H
DOI：
10.1002/wnan.40
发表时间：
2009-07
影响因子：
8.6
作者：
Canelas, Dorian A.;Herlihy, Kevin P.;DeSimone, Joseph M.
通讯作者：
DeSimone, Joseph M.
影响因子：
5.7
作者：
Fang, Jun;Qin, Haibo;Maeda, Hiroshi
通讯作者：
Maeda, Hiroshi
影响因子：
3.3
作者：
Cyran, Clemens C.;Sennino, Barbara;Fu, Yanjun;Rogut, Victor;Shames, David M.;Chaopathomkul, Bundit;Wendland, Michael F.;McDonald, Donald M.;Brasch, Robert C.;Raatschen, Hans-Juergen
通讯作者：
Raatschen, Hans-Juergen
影响因子：
78.8
作者：
Jain, Rakesh K.;Stylianopoulos, Triantafyllos
通讯作者：
Stylianopoulos, Triantafyllos