Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C infection.
Reduced mother-to-child transmission of HIV associated with infant but not maternal GB virus C infection.
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DOI：
10.1086/587488
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发表时间：
2008-05
期刊：
影响因子：
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通讯作者：
W. Supapol;R. Remis;J. Raboud;M. Millson;J. Tappero;R. Kaul;P. Kulkarni;M. Mcconnell;P. Mock;M. Culnane;J. Mcnicholl;A. Roongpisuthipong;T. Chotpitayasunondh;N. Shaffer;S. Butera
中科院分区：
文献类型：
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作者：
W. Supapol;R. Remis;J. Raboud;M. Millson;J. Tappero;R. Kaul;P. Kulkarni;M. Mcconnell;P. Mock;M. Culnane;J. Mcnicholl;A. Roongpisuthipong;T. Chotpitayasunondh;N. Shaffer;S. Butera
BACKGROUND Prolonged coinfection with GB virus C (GBV-C) has been associated with improved survival in human immunodeficiency virus (HIV)-infected adults. We investigated whether maternal or infant GBV-C infection was associated with mother-to-child transmission (MTCT) of HIV-1 infection. METHODS The study population included 1364 HIV-infected pregnant women enrolled in 3 studies of MTCT of HIV in Bangkok, Thailand (the studies were conducted from 1992-1994, 1996-1997, and 1999-2004, respectively). We tested plasma collected from pregnant women at delivery for GBV-C RNA, GBV-C antibody, and GBV-C viral genotype. If GBV-C RNA was detected in the maternal samples, the 4- or 6-month infant sample was tested for GBV-C RNA. The rates of MTCT of HIV among GBV-C-infected women and infants were compared with the rates among women and infants without GBV-C infection. RESULTS The prevalence of GBV-C RNA in maternal samples was 19%. Of 245 women who were GBV-C RNA positive, 101 (41%) transmitted GBV-C to their infants. Of 101 infants who were GBV-C RNA positive, 2 (2%) were infected with HIV, compared with 162 (13%) of 1232 infants who were GBV-C RNA negative (odds ratio [OR] adjusted for study, 0.13 [95% confidence interval {CI}, 0.03-0.54]). This association remained after adjustment for maternal HIV viral load, receipt of antiretroviral prophylaxis, CD4(+) count, and other covariates. MTCT of HIV was not associated with the presence of GBV-C RNA (adjusted OR [aOR], 0.94 [95% CI, 0.62-1.42]) or GBV-C antibody (aOR, 0.90 [95% CI, 0.54-1.50]) in maternal samples. CONCLUSIONS Reduced MTCT of HIV was significantly associated with infant acquisition of GBV-C but not with maternal GBV-C infection. The mechanism for this association remains unknown.
