Influences on the fusimotor-muscle spindle system from chemosensitive nerve endings in cervical facet joints in the cat:: possible implications for whiplash induced disorders
Influences on the fusimotor-muscle spindle system from chemosensitive nerve endings in cervical facet joints in the cat:: possible implications for whiplash induced disorders
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DOI：
10.1016/s0304-3959(00)00415-2
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发表时间：
2001-03-01
期刊：
影响因子：
7.4
通讯作者：
Johansson, H
中科院分区：
文献类型：
--
作者：
Thunberg, J;Hellström, F;Johansson, H
本研究旨在探讨颈椎小关节内的韧带结构与颈后肌的梭运动系统是否存在反射联系。在7只猫中，用α-氯醛糖麻醉，将浓度在12 μ g和50 μ g之间的缓激肽（BK）注射到C1和C2之间的小关节中。记录来自于对侧阔肌和夹肌（TrSp）的单个肌梭传入（MSA）。通过记录对TrSp肌肉正弦拉伸的反应来评估肌梭传入的敏感性的梭动诱导的变化。放电的平均速率和拟合正弦的调制深度作为响应的定量估计。共记录了25例MSA，其中21例在对侧小关节注射BK后对正弦拉伸的反应发生了明显的变化。大多数的响应传入（13/21）显示其反应的变化，表明静态梭运动神经元的活动增加，虽然也看到了动态和混合静态和动态性质的反应。局部麻醉应用于关节内受体取消的影响。注射（i.v）全身麻醉剂（戊巴比妥）消除了这种影响。结果表明，颈椎小关节感受器与颈后肌梭运动神经元之间存在反射联系，这可能对颈椎挥鞭样损伤相关疾病（WAD）的病理生理学研究具有重要意义。(C)2001年国际疼痛研究协会。由Elsevier Science B. V.出版，版权所有。
The aim of the present study was to establish if there exists reflex connections from ligamentous structures in cervical facet joints and the fusimotor system of dorsal neck muscles. In seven cats, anaesthetized with alpha -chloralose, bradykinin (BK) of concentrations between 12 and 50 mug was injected into the facet joint between C1 and C2. Recordings were made from single muscle spindle afferents (MSA) originating in contralateral trapezius and splenius muscles (TrSp). Fusimotor induced changes in the sensitivity of the muscle spindle afferents were assessed by recording the responses to sinusoidal stretches of the TrSp muscles. The mean rate of discharge and the depth of modulation of a fitted sine were taken as quantitative estimates of the response. A total of 25 MSAs were recorded, and 21 of these showed clear-cut alterations in their responses to the sinusoidal stretches following Bk. injections into contralateral facet joint. The majority of the responding afferents (13/21) showed changes in their responses indicating an increased activity of static fusimotoneurones, although responses of dynamic and mixed static and dynamic nature were also seen. Local anaesthetics applied to the intraarticular receptors abolished the effects. Injection (i.v,) of a general anaesthetic (pentobarbital) abolished the effects.. The results show that there exist reflex connections between receptors in cervical facet joints and fusimotoneurones of dorsal neck muscles, and this might be of importance in the pathophysiology behind whiplash associated disorders (WAD). (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.