Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).
Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).
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通过抗原和细菌脂多糖（内毒素）终止小鼠对人丙种球蛋白的耐受性。
DOI：
10.1084/jem.137.3.740
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发表时间：
1973-03-01
期刊：
影响因子：
--
通讯作者：
Weigle WO
中科院分区：
文献类型：
--
作者：
Chiller JM;Weigle WO
细菌脂多糖（内毒素）允许绕过胸腺源性(T)细胞辅助功能，否则需要小鼠对人γ球蛋白（HGG）的抗体反应。以类似的方式，在骨髓源性(B)细胞失去其无反应性时，对HGG的耐受状态可以通过注射免疫原性HGG和内毒素来终止，但两者都不能单独给予。然而，当B细胞具有耐受性时，采用该方案对HGG耐受性没有影响。在B细胞从耐受中自发恢复后，似乎在该群体中发生了特异性启动。这种现象可以通过注射内毒素和HGG或将细胞过继转移到受辐照的宿主中观察到。这些数据已经讨论了潜在的自身免疫表现，理论上可能遵循同时革兰氏阴性细菌感染和自身抗原的释放。
Bacterial lipopolysaccharides (endotoxin) allowed the circumvention of the thymus-derived (T) cell helper function otherwise required for the antibody response in mice to human gamma globulin (HGG). In an analogous fashion, the state of tolerance to HGG, existing at a time when bone marrow-derived (B) cells had lost their unresponsiveness, could be terminated by the injection of both immunogenic HGG and endotoxin, but by neither given alone. However, no effect on tolerance to HGG could be observed when this regimen was followed at a time when B cells were tolerant. After the spontaneous recovery from tolerance in B cells, it seemed that specific priming was occurring in that population. This phenomenon was observed either by the injection of endotoxin and HGG or by the adoptive transfer of cells into irradiated hosts. These data have been discussed in the light of potential autoimmune manifestations that could theoretically follow a simultaneous gram-negative bacterial infection along with a release of self-antigen.