Acute marijuana effects on rCBF and cognition: a PET study.
Acute marijuana effects on rCBF and cognition: a PET study.
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大麻对 rCBF 和认知的急性影响：一项 PET 研究。
DOI：
10.1097/00001756-200011270-00047
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发表时间：
2000
期刊：
影响因子：
1.7
通讯作者：
Hichwa,RD
中科院分区：
文献类型：
--
作者：
O'Leary,DS;Block,RI;Flaum,M;Schultz,SK;BolesPonto,LL;Watkins,GL;Hurtig,RR;Andreasen,NC;Hichwa,RD
The effects of smoking marijuana on cognition and brain function were assessed with PET using H 2 15 O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smoking in a number of paralimbic brain regions (eg orbital frontal lobes, insula, temporal poles) and in anterior cingulate and cerebellum. Large reductions in rCBF were observed in temporal lobe regions that are sensitive to auditory attention effects. Brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication.
