Estrogen receptor-alpha knockouts and maternal memory in nulliparous rats
Estrogen receptor-alpha knockouts and maternal memory in nulliparous rats
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DOI：
10.1016/j.yhbeh.2019.02.002
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发表时间：
2019-04-01
影响因子：
3.5
通讯作者：
Bridges, R. S.
中科院分区：
文献类型：
--
作者：
Gallagher, J. M.;Nephew, B. C.;Bridges, R. S.
本研究探讨了雌激素受体α（Esr 1）在大鼠母体记忆中的作用，比较了Esr 1敲除（KO）和野生型（WT）未经产大鼠对寄养幼崽的诱导和保留反应。在完成诱导试验后30天，对受试者在其家中笼中的母性护理保持力进行测试，然后在新笼中测试母性行为。在初始诱导试验期间，WT和Esr1 KO雌性动物对寄养幼仔的反应相似。同样，在饲养笼中进行母体记忆测试期间，Esr1 KO和WT组显示完全母体反应性的再诱导潜伏期相似。然而，在新型笼试验中，WT受试者在孕产妇护理方面表现出适度的变化。WT雌性动物首次取回和喂食试验幼仔的时间较短。这些研究结果表明，虽然Esr1似乎并不影响建立母亲的照顾或母亲的记忆的显示，它可能会调节方面的小狗导向的行为与再诱导的母亲照顾雌性大鼠。
The current study investigated the role of estrogen receptor alpha (Esr1) in maternal memory in rats, comparing the induction and retention responses of Esr1 knockout (KO) and wild type (WT) nulliparous rats towards foster pups. Thirty days after completion of induction testing, subjects were tested for the retention of maternal care in their home cage and then for maternal behaviors in a novel cage. Both WT and Esr1 KO females displayed similar latencies to respond to foster young during the initial induction testing. Likewise, reinduction latencies to display full maternal responsiveness were similar in the Esr1 KO and WT groups during maternal memory testing in the home cage. However, in the novel cage testing WT subjects displayed modest modifications in maternal care. WT females had shorter latencies to first retrieve and mouth a test pup. These findings suggest that while Esr1 does not appear to affect the establishment of maternal care or the display of maternal memory, it may modulate aspects of pup-directed behaviors associated with the reinduction of maternal care in female rats.