Arsenic and non-malignant lung disease
Arsenic and non-malignant lung disease
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DOI：
10.1080/10934520701566926
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发表时间：
2007-10-01
影响因子：
2.1
通讯作者：
Mazumder, D. N. Guha
中科院分区：
文献类型：
--
作者：
Mazumder, D. N. Guha
已发现世界各地许多含水层受到砷污染，浓度超过0.05毫克/升。然而，印度和孟加拉国大量受影响的人数是前所未有的。特征性皮肤病变（色素沉着、色素脱失和角化病）是慢性砷中毒的标志性体征。新的证据表明，通过饮用水摄入砷也可能导致非恶性呼吸系统影响。早在1970年，就有关于长期摄入砷对肺部非恶性影响的早期报告，来自智利儿童的研究。然而，在个案研究的基础上，1997年首次报道了西孟加拉饮用砷污染水后成人慢性砷中毒的呼吸影响。在西孟加拉对7683人进行的流行病学研究表明，与皮肤正常且暴露于低水平砷的个体相比，患有砷诱导皮肤病变且当前饮用水源中砷水平高（>= 0.5 mg/L）的参与者的患病率比值比（POR）估计值显著增加（
Many aquifers in various parts of the world have been found to be contaminated with arsenic at concentration above 0.05 mg/L. However reports of large number of affected people in India and Bangladesh are unprecedented. Characteristic skin lesions (pigmentation, depigmentation and keratosis) are the hallmark signs of chronic arsenic toxicity. Emerging evidences show that ingestion of arsenic through drinking water may also lead to non-malignant respiratory effects. Early report of non-malignant pulmonary effect of chronic ingestion of arsenic was available from studies in children in Chile as early as 1970. However on the basis of case studies, respiratory effect of chronic arsenic toxicity in adults following dinking of arsenic contaminated water in West Bengal was first reported in 1997. Epidemiological studies carried out in West Bengal on a population of 7683 showed that the prevalence odds ratio (POR) estimates were markedly increased for participants with arsenic induced skin lesions who also had high levels of arsenic in their current drinking water source (>= 0.5 mg/L) compared with individuals who had normal skin and were exposed to low levels of arsenic (