The 3D structure of protein phosphatase 2A: New insights into a ubiquitous regulator of cell signaling
The 3D structure of protein phosphatase 2A: New insights into a ubiquitous regulator of cell signaling
复制标题
DOI：
10.1021/cb700021z
复制
发表时间：
2007-02-01
影响因子：
4
通讯作者：
Mumby, Marc
中科院分区：
文献类型：
--
作者：
Mumby, Marc
蛋白磷酸酶2A（PP 2A）是一种与癌症有关的丝氨酸/苏氨酸磷酸酶。PP 2A的三种新晶体结构显示了它如何与抑制性毒素及其调节亚基之一相互作用。这些结构还解释了特定位点突变如何导致癌症，并提出了PP 2A甲基化在PP 2A全酶形成中的新作用。
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in cancer. Three new crystal structures of PP2A show how it interacts with inhibitory toxins and with one of its regulatory subunits. The structures also explain how specific site mutations may lead to cancer and suggest a novel role for PP2A methylation in the formation of PP2A holoenzymes.