A randomized trial of lottery-based incentives and reminders to improve warfarin adherence: the Warfarin Incentives (WIN2) Trial.
A randomized trial of lottery-based incentives and reminders to improve warfarin adherence: the Warfarin Incentives (WIN2) Trial.
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DOI：
10.1002/pds.4094
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发表时间：
2016-11
影响因子：
2.6
通讯作者：
Volpp, Kevin
中科院分区：
文献类型：
--
作者：
Kimmel, Stephen E.;Troxel, Andrea B.;French, Benjamin;Loewenstein, George;Doshi, Jalpa A.;Hecht, Todd E. H.;Laskin, Mitchell;Brensinger, Colleen M.;Meussner, Chris;Volpp, Kevin
以前的研究表明，每天的彩票奖励可以提高药物依从性。这种日常激励包括隐性提醒。然而，提醒单与每日奖励的比较效力尚未得到检验。270例接受华法林治疗的患者参加了一项4臂、多中心、随机对照试验，将每日抽奖激励、每日提醒以及两者结合与对照组（常规护理）进行比较。提醒组参与者的时间超出目标国际标准化比值（INR）范围（主要结局）的百分比最低，调整后的INR超出范围的比值比对照组低36%，95%CI：（7%，55%）。与对照组或其他组相比，其他组的抗凝控制均无统计学显著性改善。唯一在不正确依从性方面有显著改善的组是彩票组（不正确依从性：12.1%，对照组为23.7%，差异为-7.4%95%CI：[-14%，-0.3%]）。然而，彩票组的依从性变化与抗凝控制之间没有关系。自动提醒导致抗凝控制的最大改善，但不影响测量的依从性。基于抽奖的提醒改善了测量的依从性，但没有改善抗凝控制。
Previous research has suggested that daily lottery incentives could improve medication adherence. Such daily incentives include implicit reminders. However, the comparative effectiveness of reminders alone versus daily incentives has not been tested. 270 patients on warfarin were enrolled in a 4-arm, multi-center, randomized controlled trial comparing a daily lottery-based incentive, a daily reminder, and a combination of the two against a control group (usual care). Participants in the reminder group had the lowest percentage of time out of target international normalized ratio (INR) range, the primary outcome, with an adjusted odds of an out-of-range INR 36% lower than among those in the control group, 95% CI: (7%, 55%). No other group had a statistically significant improvement in anticoagulation control relative to the control group or to each other. The only group that had significant improvement in incorrect adherence was the lottery group (incorrect adherence: 12.1% compared to 23.7% in the control group, difference of −7.4% 95% CI: [−14%, −0.3%]). However, there was no relationship between changes in adherence and anticoagulation control in the lottery group. Automated reminders led to the largest improvements in anticoagulation control, though without impacting measured adherence. Lottery-based reminders improved measured adherence, but did not lead to improved anticoagulation control.
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影响因子：
120.7
作者：
Volpp, Kevin G.;John, Leslie K.;Troxel, Andrea B.;Norton, Laurie;Fassbender, Jennifer;Loewenstein, George
通讯作者：
Loewenstein, George
影响因子：
2.8
作者：
Volpp KG;Loewenstein G;Troxel AB;Doshi J;Price M;Laskin M;Kimmel SE
通讯作者：
Kimmel SE
影响因子：
4.8
作者：
Kimmel SE;Troxel AB;Loewenstein G;Brensinger CM;Jaskowiak J;Doshi JA;Laskin M;Volpp K
通讯作者：
Volpp K
影响因子：
39.2
作者：
Go, AS;Hylek, EM;Singer, DE
通讯作者：
Singer, DE
影响因子：
6.1
作者：
Camerer, C;Ho, TH
通讯作者：
Ho, TH