Circulating immunoreactive interleukin-6 in cystic fibrosis
Circulating immunoreactive interleukin-6 in cystic fibrosis
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DOI：
10.1164/ajrccm.157.6.9704086
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发表时间：
1998-06-01
影响因子：
24.7
通讯作者：
Shale, DJ
中科院分区：
文献类型：
--
作者：
Nixon, LS;Yung, B;Shale, DJ
我们检测了急性加重期、抗生素治疗后和临床稳定的囊性纤维化和慢性肺部感染铜绿假单胞菌感染患者外周血和痰中白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、中性粒细胞弹性蛋白酶-α(1)-抗蛋白酶复合体(NEAPC)和C反应蛋白(CRP)的浓度。目的是确定促炎和抗炎细胞因子在囊性纤维化中与其他炎症活性标记物的间隔模式。抗生素治疗后IL-6、NEAPC、CRP和中性粒细胞绝对数均降低，P<；0.01。在病情稳定的患者组中，IL-6和C反应蛋白的浓度分别高于病情加重末期的患者，p=0.007和p=0.01。IL-6与C反应蛋白浓度呈正相关(r=0.836，p<；0.0001)，且在研究的所有时间均高于匹配对照组(p<；0.001)。治疗后痰中IL-6浓度与FEV1、FVC呈正相关，与中性粒细胞弹性蛋白酶浓度呈负相关。患者和健康受试者之间的分离，以及抗生素治疗后IL-6的降低表明它可以被用作炎症的标志，但它与其他标志的关系取决于它被测量的间隔。
We measured circulating and sputum-sol concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), neutrophil elastase-alpha(1)-antiproteinase complex (NEAPC), and C-reactive protein (CRP) in an exacerbation, after antibiotic treatment, and in clinically stable patients with cystic fibrosis and chronic pulmonary infection with Pseudomonas aeruginosa. The aim was to determine the compartmental patterns of a proinflammatory and anti-inflammatory cytokine compared with other markers of inflammatory activity in cystic fibrosis. IL-6, NEAPC, CRP, and absolute neutrophil count were reduced after antibiotic treatment, p < 0.01. IL-6 and CRP concentrations were greater, p = 0.007, and p = 0.01, respectively, in a stable group of patients compared with those at the end of an exacerbation. IL-6 and CRP concentrations were related (r = 0.836, p < 0.0001), and both were greater than in matched control subjects (p < 0.001) at all times studied. Sputum-sol concentrations of IL-6 after treatment were positively related to FEV1 and FVC and inversely related to concentrations of neutrophil elastase. The separation between patients and healthy subjects, and the reduction of IL-6 after antibiotic treatment indicates it could be used as a marker of inflammation, but its relationship to other markers depends on the compartment in which it is measured.