MANAGING INDUSTRIAL PHARMACEUTICAL RESEARCH-AND-DEVELOPMENT - A COMPARATIVE-STUDY OF MANAGEMENT CONTROL AND INNOVATIVE EFFECTIVENESS IN EUROPEAN AND ANGLO-AMERICAN COMPANIES
MANAGING INDUSTRIAL PHARMACEUTICAL RESEARCH-AND-DEVELOPMENT - A COMPARATIVE-STUDY OF MANAGEMENT CONTROL AND INNOVATIVE EFFECTIVENESS IN EUROPEAN AND ANGLO-AMERICAN COMPANIES
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工业药品研发管理——欧美企业管理控制与创新有效性的比较研究
DOI：
10.1111/j.1467-9310.1994.tb00886.x
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
J. V. Engelen
中科院分区：
文献类型：
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作者：
S. Omta;L. Bouter;J. V. Engelen
药品监管和定价给创新医药行业的成本效益比带来了很大压力。因此，对14家大中型企业进行了一项研究，以确定影响药品创新成功的一些重要组织和管理因素。这项研究包括对研究主管的结构化访谈和提交给不同研究部门负责人的调查问卷。现初步得出以下结论。首先，数据表明，要保持创新潜力，需要大约1.5亿至2亿美元的门槛投资。在大约7.5亿美元以上，“规模经济”似乎出现在药品创新领域。其次，旨在缩短开发过程持续时间的渐进式战略似乎比更强调发现的激进战略更成功。第三，纯粹的制药似乎比企业集团的制药部门更成功。管理控制，尤其是重组的执行方式，在纯粹的制药公司中得到了更积极的评估。第四，与欧洲大陆公司相比，英美公司更加重视人力资源管理，这似乎是他们在药品市场上取得更大成功的一个重要解释因素。
Drug regulation and pricing have put strong pressure on the cost-benefit ratio of the innovative pharmaceutical industry. Therefore a study has been conducted in fourteen large and medium sized companies to determine some important organisational and managerial factors influencing success in pharmaceutical innovation. The study consists of structured interviews with Research Directors and questionnaires, submitted to the heads of the different research departments. The following conclusions are tentatively drawn. Firstly, the data suggest that a threshold investment of approximately $150-200 million is needed to maintain the innovative potential. Above approximately $750 million, 'economies of scale' seem to appear in pharmaceutical innovation. Secondly, an incremental strategy aimed at reducing the duration of the development process seems to be more successful than a radical strategy which lays more emphasis on discovery. Thirdly, pure play pharmaceuticals seem to be more successful than the pharmaceutical divisions of conglomerates. Management control, especially the way in which reorganisations are performed, is assessed more positively in pure play pharmaceuticals. Fourthly, the greater emphasis on human resources management in Anglo-American companies, in comparison to continental European companies, seems to be an important explanatory factor for their greater success on the pharmaceutical market.