NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila.
NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila.
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DOI：
10.1016/j.mcn.2010.12.010
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发表时间：
2011-02
影响因子：
3.5
通讯作者：
Sanyal, Subhabrata
中科院分区：
文献类型：
--
作者：
Freeman, Amanda;Franciscovich, Amy;Bowers, Mallory;Sandstrom, David J.;Sanyal, Subhabrata
钙调节的转录因子NFAT正在成为神经元发育和可塑性的关键调节因子，但NFAT功能的精确细胞后果仍然知之甚少。在这里，我们报告说，单一的果蝇NFAT同系物广泛表达的神经系统，包括运动神经元和出乎意料地控制神经兴奋性。可能是由于这种对兴奋性的影响，NFAT调节整个幼虫的运动和慢性和急性形式的活动依赖性可塑性在幼虫的神经肌肉突触。具体而言，NFAT依赖性突触表型包括突触前终扣数量的变化、突触微管结构的稳定修饰和突触前递质释放，而没有发现突触收缩或突触细胞粘附分子Fas II水平改变的证据。我们认为NFAT通过抑制神经元兴奋性来调节突触前发育并限制长期可塑性。
The calcium-regulated transcription factor NFAT is emerging as a key regulator of neuronal development and plasticity but precise cellular consequences of NFAT function remain poorly understood. Here, we report that the single Drosophila NFAT homolog is widely expressed in the nervous system including motor neurons and unexpectedly controls neural excitability. Likely due to this effect on excitability, NFAT regulates overall larval locomotion and both chronic and acute forms of activity-dependent plasticity at the larval glutamatergic neuro-muscular synapse. Specifically, NFAT-dependent synaptic phenotypes include changes in the number of pre-synaptic boutons, stable modifications in synaptic microtubule architecture and pre-synaptic transmitter release, while no evidence is found for synaptic retraction or alterations in the level of the synaptic cell adhesion molecule FasII. We propose that NFAT regulates pre-synaptic development and constraints long-term plasticity by dampening neuronal excitability.
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.89.13.5764
发表时间：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
Freeman, Amanda;Bowers, Mallory;Mortimer, Alysia Vrailas;Timmerman, Christina;Roux, Stephanie;Ramaswami, Mani;Sanyal, Subhabrata
通讯作者：
Sanyal, Subhabrata