Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation
Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation
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DOI：
10.1016/j.ceb.2020.10.008
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发表时间：
2021-02-01
影响因子：
7.5
通讯作者：
Echarri, Asier
中科院分区：
文献类型：
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作者：
Del Pozo, Miguel A.;Lolo, Fidel-Nicolas;Echarri, Asier
到达质膜（PM）的机械力（细胞外基质硬度、血管剪切应力和肌肉拉伸）决定细胞行为。小窝是具有特定脂质和蛋白质组成的PM内陷纳米结构域。由于在机械挑战组织（肌肉，肺，血管和脂肪组织）中含量很高，它们可以保护细胞免受机械应力损伤。小窝变平后增加PM张力，使力传感和住宿，细胞的机械保护和稳态的关键。因此，小窝是高度可塑性的，复杂性从扁平膜到被小窝包围的空泡内陷-这也有助于机械保护。小窝成分与机械力信号转导通路发生串扰，最近的研究表明它们从PM易位到核来传递应力信息。此外，小窝组件可以调节来自/去往PM的膜交通以适应环境机械力。脂质和小窝之间的相互依赖性开始被理解，小窝依赖性膜运输与机械适应不同的生理病理过程的相关性正在出现。
Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM-invaginated nanodomains with specific lipid and protein composition. Being highly abundant in mechanically challenged tissues (muscles, lungs, vessels, and adipose tissues), they protect cells from mechanical stress damage. Caveolae flatten upon increased PM tension, enabling both force sensing and accommodation, critical for cell mechanoprotection and homeostasis. Thus, caveolae are highly plastic, ranging in complexity from flattened membranes to vacuolar invaginations surrounded by caveolae-rosettes-which also contribute to mechanoprotection. Caveolar components crosstalk with mechanotransduction pathways and recent studies show that they translocate from the PM to the nucleus to convey stress information. Furthermore, caveolae components can regulate membrane traffic from/to the PM to adapt to environmental mechanical forces. The interdependence between lipids and caveolae starts to be understood, and the relevance of caveolae-dependent membrane trafficking linked to mechanoadaption to different physiopathological processes is emerging.