Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B
Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B
复制标题
DOI：
10.1039/b806712k
复制
发表时间：
2008-09-21
影响因子：
3.2
通讯作者：
Wipf, Peter
中科院分区：
文献类型：
--
作者：
Keinan, Shahar;Paquette, William D.;Wipf, Peter
Quinoid inhibitors of Cdc25B were designed based oil the Linear Combination of Atomic potentials (LCAP) methodology. In contrast to it published hypothesis. the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the (quinone half-wave potential, E-1/2.
