PROTECTION OF MICE AGAINST AUJESZKYS-DISEASE VIRUS-INFECTION BY INTRANASAL VACCINATION WITH INACTIVATED VIRUS
PROTECTION OF MICE AGAINST AUJESZKYS-DISEASE VIRUS-INFECTION BY INTRANASAL VACCINATION WITH INACTIVATED VIRUS
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DOI：
10.1292/jvms.56.633
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发表时间：
1994-08-01
影响因子：
1.2
通讯作者：
KIDA, H
中科院分区：
文献类型：
--
作者：
TAKADA, A;SHIMIZU, Y;KIDA, H
用灭活的Aujeszky病病毒（ADV）鼻内接种小鼠，在呼吸道分泌物中诱导对该病毒的伊加和IgG抗体应答，从而完全保护动物免受强毒ADV的鼻内攻击。通过使用霍乱毒素B亚单位（CT B）作为佐剂来增强免疫应答。另一方面，用灭活的ADV皮下接种小鼠，即使与CTB一起，也几乎不刺激分泌性抗体应答，仅产生部分保护。目前的结果表明，开发一种疫苗接种程序，以刺激粘膜免疫应答，应提高灭活疱疹病毒疫苗的保护作用，从而使其有可能通过禁止病毒复制的网站，其中原发感染发生，以及抑制随后的潜伏期和再激活的病毒来控制感染。
Intranasal vaccination of mice with inactivated Aujeszky's disease virus (ADV) induced IgA and IgG antibody responses to the virus in the secretion of the respiratory tract, resulting in complete protection of the animals against intranasal challenge with virulent ADV. The immune response was enhanced by the use of the cholera toxin B subunit (CTB) as an adjuvant. On the other hand, subcutaneous vaccination of mice with inactivated ADV, even together with CTB, scarcely stimulated secretory antibody responses, resulting in only partial protection. The present results suggest that development of a vaccination procedure to stimulate the mucosal immune response should improve the protective effects of the inactivated herpesvirus vaccines, and thereby make it possible to control the infections by prohibiting virus replication at the site where primary infection takes place, as well as inhibiting subsequent latency and reactivation of the virus.