OXYGEN-TENSION REGULATES THE EXPRESSION OF ANGIOGENESIS FACTOR BY MACROPHAGES
OXYGEN-TENSION REGULATES THE EXPRESSION OF ANGIOGENESIS FACTOR BY MACROPHAGES
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DOI：
10.1126/science.6612342
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
BANDA, MJ
中科院分区：
文献类型：
--
作者：
KNIGHTON, DR;HUNT, TK;BANDA, MJ
当在类似于伤口中心的缺氧环境中培养时，[兔]巨噬细胞将活性血管生成因子分泌到培养基中。在与氧合良好的组织相似的条件下，巨噬细胞不分泌活性血管生成因子。在缺氧条件下分泌该因子的巨噬细胞在回到室内空气时停止分泌。因此，伤口愈合中血管生成的控制可能是巨噬细胞对组织氧张力做出反应的结果，而无需与其他细胞类型或生化信号相互作用。
When cultured in a hypoxic environment similar to that found in the center of a wound, [rabbit] macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those of well-oxygenated tissue, macrophages did not secrete active angiogenesis factor. Macrophages that secreted the factor at hypoxic conditions stopped secreting it when returned to room air. Thus the control of angiogenesis in wound healing may be the result of macrophages responding to tissue O2 tension without the necessity of interacting with other cell types or biochemical signals.