Salience and Default Mode Network Coupling Predicts Cognition in Aging and Parkinson's Disease.
Salience and Default Mode Network Coupling Predicts Cognition in Aging and Parkinson's Disease.
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DOI：
10.1017/s1355617715000892
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Stern CE
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文献类型：
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作者：
Putcha D;Ross RS;Cronin-Golomb A;Janes AC;Stern CE
认知功能障碍在帕金森病（PD）中很常见。三个神经认知网络支持有效的认知：显着性网络，默认模式网络和中央执行网络。显着性网络被认为在激活和停用默认模式和中央执行网络之间切换。特别是显着性和默认模式网络之间的反相关相互作用对于有效的认知是必要的。我们以前的工作表明，与年龄匹配的对照参与者相比，非痴呆PD患者的神经认知网络之间的功能耦合发生了改变。在这里，我们的目标是确定在同一组参与者中这些神经认知网络之间的认知和功能耦合之间的关联。我们调查了这些神经认知网络之间的内在功能耦合与三个神经心理学领域的认知表现相关的程度：执行功能，心理速度和言语记忆。24名轻度至中度PD的非痴呆个体和20名对照参与者在休息时进行扫描，并在三个神经心理学领域进行评估。与对照组相比，PD参与者在所有三个领域的测试中受损。我们的成像结果表明，健康老龄化和帕金森病参与者的成功认知与显着性和默认模式网络之间的反相关耦合有关。各组中表现评分较差的个体表现出更积极的SN-DMN偶联。成功的认知依赖于显著性和默认模式网络之间的健康耦合，这可能在PD中变得功能失调。这些结果可以帮助在这些特定网络在帕金森病的早期阶段变得脆弱之前，为针对这些特定网络的非药物干预（rTMS）提供信息。
Cognitive impairment is common in Parkinson’s disease (PD). Three neurocognitive networks support efficient cognition: the salience network, the default mode network, and the central executive network. The salience network is thought to switch between activating and deactivating the default mode and central executive networks. Anti-correlated interactions between the salience and default mode networks in particular are necessary for efficient cognition. Our previous work demonstrated altered functional coupling between the neurocognitive networks in non-demented individuals with PD compared to age-matched control participants. Here, we aim to identify associations between cognition and functional coupling between these neurocognitive networks in the same group of participants. We investigated the extent to which intrinsic functional coupling among these neurocognitive networks is related to cognitive performance across three neuropsychological domains: executive functioning, psychomotor speed, and verbal memory. Twenty-four non-demented individuals with mild to moderate PD and twenty control participants were scanned at rest and evaluated on three neuropsychological domains. PD participants were impaired on tests from all three domains compared to control participants. Our imaging results demonstrated that successful cognition across healthy aging and Parkinson’s disease participants was related to anti-correlated coupling between the salience and default mode networks. Individuals with poorer performance scores across groups demonstrated more positive SN-DMN coupling. Successful cognition relies on healthy coupling between the salience and default mode networks, which may become dysfunctional in PD. These results can help inform non-pharmacological interventions (rTMS) targeting these specific networks before they become vulnerable in early stages of Parkinson’s disease.