When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease
When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease
复制标题
DOI：
10.4414/smw.2016.14347
复制
发表时间：
2016-09-15
影响因子：
2.9
通讯作者：
Vaccari, Thomas
中科院分区：
文献类型：
--
作者：
Alfred, Victor;Vaccari, Thomas
ESCRT（运输所需的内体分选复合物）蛋白最初被发现是内体运输过程中货物分选的调节剂，现在正成为塑造整个细胞膜行为的灵活机器。在神经退行性疾病、病毒感染和癌症中观察到ESCRT活性的失调。然而，涉及ESCRT的发病机制尚未完全成为焦点。在这里，我们回顾了ESCRT在健康和疾病中的功能的现有知识，并为未来的研究和集中的治疗干预提供了有根据的猜测。
Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention.