ThermoTRPs and Pain.
ThermoTRPs and Pain.
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Thermotrps和疼痛。
DOI：
10.1177/1073858414567884
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Dhaka A
中科院分区：
文献类型：
--
作者：
Laing RJ;Dhaka A
身体感知有害刺激的能力在于一组异质的初级体感神经元，称为伤害感受器。有害机械、温度或化学刺激的分子受体在这些神经元中表达，并作为镇痛药物开发的可能靶点引起了相当大的关注，以改善数百万慢性疼痛患者的治疗。许多 ThermoTRP 是离子通道瞬时受体电位家族的一个子集，可被多种有害刺激激活。在这篇综述中，我们回顾了这些通道的功能，并检查了 ThermoTRP 在急性、炎症和神经性伤害感受中发挥重要作用的证据。
The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors. The molecular receptors of noxious mechanical, temperature or chemical stimuli are expressed in these neurons and have drawn considerable attention as possible targets for analgesic development to improve treatment for the millions who suffer from chronic pain conditions. A number of thermoTRPs, a subset of the transient receptor potential family of ion channels, are activated by a wide range on noxious stimuli. In this review, we review the function of these channels and examine the evidence that thermoTRPs play a vital role in acute, inflammatory and neuropathic nociception.