Mechanism of origin of complete hydatidiform moles
Mechanism of origin of complete hydatidiform moles
复制标题
完全性葡萄胎的起源机制
DOI：
10.1097/00006254-198105000-00023
复制
发表时间：
1980
期刊：
影响因子：
64.8
通讯作者：
B. Migeon
中科院分区：
文献类型：
--
作者：
P. Jacobs;C. M. Wilson;J. A. Sprenkle;N. Rosenshein;B. Migeon
完全性或“真性”葡萄胎是人类妊娠的一种异常，其特征是所有胎盘绒毛水肿变性，滋养层明显肥大，胎儿缺失，并有恶变的倾向。完全性葡萄胎的染色体组成通常为46，XX 1，2，Kajii等人报告称，7例病例中有7例的整个基因组起源于父系，所有着丝粒标记均为父系异型纯合3。这些观察结果，因为确认4，5，可以解释为受精的'空'鸡蛋-没有有效的基因组-通过一个单倍体精子，然后复制没有胞质分裂，恢复二倍体数量，或通过二倍体精子导致第二次减数分裂失败。我们在这里报告的一系列完整的痣，表明第一个选择是正确的，在大多数情况下的研究。
Complete or ‘true’ hydatidiform mole, an abnormality of human gestation, is characterized by hydropic degeneration of all placental villi, marked hypertrophy of the trophoblast, absence of a fetus and a propensity to become malignant. The chromosome constitution of complete moles is usually 46,XX1,2, and Kajii et al. reported that the entire genome in seven out of seven cases was paternal in origin, with all centromere markers homozygous for paternal heteromorphisms3. These observations, since confirmed4,5, can be explained by the fertilization of an ‘empty’ egg—no effective genome—by either a haploid sperm that then duplicates without cytokinesis, to restore the diploid number, or by a diploid sperm resulting from failure of the second meiotic division. We report here a study of a series of complete moles that shows the first alternative to be correct in the majority of cases.