Lung Cancer Risk and Consumption of Vegetables and Fruit: An Evaluation Based on a Systematic Review of Epidemiological Evidence from Japan
Lung Cancer Risk and Consumption of Vegetables and Fruit: An Evaluation Based on a Systematic Review of Epidemiological Evidence from Japan
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DOI：
10.1093/jjco/hyr027
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发表时间：
2011-05-01
影响因子：
2.4
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Wakai, Kenji;Matsuo, Keitaro;Tsugane, Shoichiro
目的：β-胡萝卜素补充剂的临床试验和最近的大规模前瞻性研究对蔬菜和水果消费对肺癌的保护作用提出了质疑。为了重新评估这个问题，我们回顾了日本流行病学研究的数据。方法：原始数据来自MEDLINE和日本Centra Revuo Medicina（Ichushi）数据库的搜索。协会进行了评估的基础上，他们的规模和证据的强度，连同他们的生物accessibility，如以前评估的国际癌症研究机构onCancer.Results：我们确定了6个队列研究和4个病例对照研究的蔬菜和/或水果的消费。我们把水果和黄绿色蔬菜作为食物，因为它们被纳入了更多的研究，而其他类型的蔬菜的数据不足。在三项队列研究和两项病例对照研究中，每种研究类型中只有一项显示肺癌风险与其消费量之间存在微弱的负相关。四项队列研究中的两项和四项病例对照研究中的一项（或可能两项）表明，肺癌风险与水果消费之间存在弱负相关。水果消费的荟萃分析显示，一个总结的相对风险是显着小于unity.Conclusions：我们的分析日本的流行病学数据表明，水果消费可能会降低肺癌的风险，但没有发现足够的证据与蔬菜消费的联系。进一步的前瞻性研究应评估食用这些食物组的影响。
Objective: Clinical trials of beta-carotene supplementation and recent large-scale prospective studies have called into question the protective effects of vegetable and fruit consumption against lung cancer. To re-assess this issue, we reviewed data from Japanese epidemiological studies.Methods: Original data were obtained from searches of MEDLINE and the Japana Centra Revuo Medicina (Ichushi) database. The associations were assessed based on their magnitude and the strength of the evidence, together with their biological plausibility as previously evaluated by the International Agency for Research on Cancer.Results: We identified six cohort studies and four case-control studies on the consumption of vegetables and/or fruit. We focused on fruit and green-yellow vegetables as food items, as they were included in more of the studies, and insufficient data were available on other types of vegetables. Among the three cohort and two case-control studies that reported on green-yellow vegetables, only one of each study type showed a weak inverse association between lung cancer risk and their consumption. Two of the four cohort studies and one (or possibly two) of the four case-control studies demonstrated a weak inverse correlation between lung cancer risk and fruit consumption. Meta-analysis for fruit consumption revealed a summary relative risk that was significantly smaller than unity.Conclusions: Our analysis of the Japanese epidemiological data showed that fruit consumption possibly decreased the risk of lung cancer, but found insufficient evidence of a link with vegetable consumption. Further prospective studies should assess the effects of consuming these food groups.