Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries
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DOI：
10.1152/ajprenal.1998.275.3.f370
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发表时间：
1998-09-01
影响因子：
4.2
通讯作者：
Roman, RJ
中科院分区：
文献类型：
--
作者：
Alonso-Galicia, M;Sun, CW;Roman, RJ
The present study examined the contribution of elevations in cGMP Versus inhibition of cytochrome P-4504A enzymes and the production of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE) to the vasodilator actions of NO in renal arterioles. The NO donor sodium nitroprusside (SNP) at 10(-5), 10(-4), and 10(-3) M reduced the production of 20-HETE in microsomes prepared from renal arterioles to 80 +/- 2, 43 +/- 5, and 7 +/- 1% of control, respectively (n = 4). In other experiments, the vasodilator response to SNP (10(-7) to 10(-3) M) was examined in rat renal interlobular arteries (
