WEIGHT AS A RISK FACTOR FOR CLINICAL DIABETES IN WOMEN
WEIGHT AS A RISK FACTOR FOR CLINICAL DIABETES IN WOMEN
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DOI：
10.1093/oxfordjournals.aje.a115686
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发表时间：
1990-09-01
影响因子：
5
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
--
作者：
COLDITZ, GA;WILLETT, WC;SPEIZER, FE
为了确定体重指数（体重/身高2）与临床非胰岛素依赖型糖尿病风险的关系，作者分析了1976年113，861名30-55岁美国女性的队列数据。在8年的随访期间（826，010人-年），在最初未诊断为糖尿病的女性中确定了873例确诊病例。在平均体重指数为23-23.9 kg/m2的妇女中，相对风险是体重指数低于22 kg/m2的妇女的3.6倍。超过这一体重指数水平，风险继续增加。作者在18岁时观察到与体重的正相关性要弱得多，并且在调整当前的体重指数后，这种相关性被消除。因此，18岁以后的体重增加是风险的主要决定因素。体重增加20-35公斤，相对危险度为11.3，体重增加35公斤以上，相对危险度为17.3。调整家族史并没有明显改变在体重指数平均水平的女性中观察到的强相关性。这些数据表明，即使是平均体重，妇女患临床非胰岛素依赖型糖尿病的风险也会增加，体重指数与糖尿病风险之间的关系是连续的。
To determine the relation of body mass index (weight/height2) with the risk of clinical non-insulin-dependent diabetes, the authors analyzed data from a cohort of 113,861 US women aged 30-55 years in 1976. During 8 years of follow-up (826,010 person-years), 873 definite cases were identified among women initially free from diagnosed diabetes. Among women of average body mass index, 23-23.9 kg/m2, the relative risk was 3.6 times that of women having a body mass index less than 22 kg/m2. The risk continued to increase above this level of body mass index. The authors observed a much weaker positive association with weight at age 18, and this association was eliminated after adjustment for current body mass index. Thus, weight gain after age 18 was a major determinant of risk. For an increase of 20-35 kg, the relative risk was 11.3, and for an increase of more than 35 kg, the relative risk was 17.3. Adjusting for family history did not appreciably alter the strong relation observed among women at average levels of body mass index. These data indicate that, at even average weight, women are at increased risk of clinical non-insulin-dependent diabetes and that the relation between body mass index and risk of diabetes is continuous.