Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT
Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT
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DOI：
10.1007/s00330-011-2316-y
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发表时间：
2012-04-01
影响因子：
5.9
通讯作者：
Murakami, Takamichi
中科院分区：
文献类型：
--
作者：
Onishi, Hiromitsu;Kim, Tonsok;Murakami, Takamichi
回顾性比较多期多探测器CT和钆塞酸二钠增强MR成像检测富血供肝细胞癌（HCC）的准确性，在伦理批准后，我们分析了31例疑似HCC患者的73个富血供HCC病灶，这些患者接受了钆塞酸二钠增强MR成像和多期多探测器CT。五名设盲观察者独立审查了CT图像以及单独的动态MR图像以及与肝胆相MR图像相结合的动态MR图像。应用Scheffe posthoc检验比较动态和肝胆期MR联合诊断的准确性（Az值）、敏感性和阳性预测值，其平均Az值（0.81）或单纯动态MR（0.78）均显著高于CT（0.67，P分别< 0.001和0.005）。MRI联合检查的平均敏感度（0.67）明显高于单纯动态MRI（0.52，P < 0.05）或CT（0.44，P < 0.05）。CT、动态MR单独成像和联合成像的平均阳性预测值分别为0.96、0.95和0.94。钆塞酸二钠增强MR成像结合动态和肝胆期图像，可显著提高检测富血供HCC的灵敏度和诊断准确性。特异性MR成像造影剂。甘氨酯钠增强MRI有助于肝脏疾病患者的评估。
To retrospectively compare the accuracy of detection of hypervascular hepatocellular carcinoma (HCC) by multiphasic multidetector CT and by gadoxetate disodium-enhanced MR imaging.After ethical approval, we analysed a total of 73 hypervascular HCC lesions from 31 patients suspected of having HCC, who underwent both gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT. Five blinded observers independently reviewed CT images, as well as dynamic MR images alone and combined with hepatobiliary phase MR images. Diagnostic accuracy (Az values), sensitivities and positive predictive values were compared by using the Scheffe post hoc test.The mean Az value for dynamic and hepatobiliary phase MR combined (0.81) or dynamic MR images alone (0.78) was significantly higher than that for CT images (0.67, P < 0.001, 0.005, respectively). The mean sensitivity of the combined MR images (0.67) was significantly higher than that of dynamic MR alone (0.52, P < 0.05) or CT images (0.44, P < 0.05). The mean positive predictive values were 0.96, 0.95 and 0.94, for CT, dynamic MR alone and combined MR images, respectively.Compared with multiphasic multidetector CT, gadoxetate disodium-enhanced MR imaging combining dynamic and hepatobiliary phase images results in significantly improved sensitivity and diagnostic accuracy for detection of hypervascular HCC.aEuro cent Gadoxetate disodium is a new liver-specific MR imaging contrast agent. Gadoxetate disodium-enhanced MRI helps the assessment of patients with liver disease.aEuro cent It showed high diagnostic accuracy for the detection of hepatocellular carcinoma.