Human granulocyte colony-stimulating factor: its basic aspects and clinical applications.
Human granulocyte colony-stimulating factor: its basic aspects and clinical applications.
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人粒细胞集落刺激因子：其基本方面和临床应用。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
S. Asano
中科院分区：
文献类型：
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作者：
S. Asano
人粒细胞集落刺激因子（G-CSF）是一种由174个氨基酸组成的20 KD糖蛋白，主要由内皮细胞、单核-巨噬细胞和成纤维细胞在感染等多种刺激下产生。该分子特异性且显着地刺激与造血干细胞/祖细胞扩增相关的中性粒细胞的产生，并提高中性粒细胞的功能活性。重组人粒细胞集落刺激因子（rhG-CSF）以其独特的生物学活性，在减少细菌/真菌感染，特别是各种原因引起的血小板减少症，增加癌症化疗药物的剂量强度，以及解决造血干细胞移植中的各种问题等方面，已成为一种划时代的药物。
Human granulocyte colony-stimulating factor (G-CSF), a 20 KD glycoprotein consisting of 174 amino acids, is one of the physiological regulators mainly produced by endothelial cells, monocytes-macrophages and fibroblasts, under various stimulations such as infections. The molecule specifically and markedly stimulates the production of neutrophils associated with an expansion of the hematopoietic stem cells/progenitor cells and elevates the functional activities of neutrophils. Under favor of the unique biological activities, recombinant human G-CSF (rhG-CSF) has now become an epoch-making agent for the purposes of reduction of bacterial/fungal infections, particularly in neutropenias of various causes, increased dose intensity of chemotherapeutic drugs in cancers, and solving various problems in hematopoietic stem cell transplantation.