Alcohol exposure in utero results in diminished T-cell function and alterations in brain corticotropin-releasing factor and ACTH content.
Alcohol exposure in utero results in diminished T-cell function and alterations in brain corticotropin-releasing factor and ACTH content.
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子宫内的酒精暴露会导致 T 细胞功能减弱以及大脑促肾上腺皮质激素释放因子和 ACTH 含量的改变。
DOI：
10.1111/j.1530-0277.1989.tb00350.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
McGivern,RF
中科院分区：
文献类型：
--
作者：
Redei,E;Clark,WR;McGivern,RF
观察孕期最后一周孕期酒精暴露对SD大鼠免疫功能、垂体促肾上腺皮质激素(ACTH)和下丘脑促肾上腺皮质激素释放因子(CRF)水平的长期致畸作用。用T淋巴细胞对ConA(3μg/mlConA)促有丝分裂刺激的免疫反应性测定了21日龄雄性Ref在宫内酒精暴露后的免疫反应。与对照组相比，酒精暴露动物的脾细胞增殖反应降低了8倍，胸腺细胞增殖反应降低了2倍。酒精暴露的雄性在出生时胸腺重量显著小于对照组，但在21日龄时显著大于对照组。在酒精暴露的男性中，也观察到ACTH和CRF激素含量的变化，这些激素被认为是免疫反应的直接或间接调节因素。酒精暴露雄性仔鼠出生后第1天下丘脑CRF含量和垂体ACTH含量显著低于对照组，而下丘脑ACTH含量显著高于对照组。这些结果表明，孕期最后一周的酒精暴露除了对免疫系统的致畸作用外，还会引起下丘脑-垂体-肾上腺功能的改变，这是以前只有在更长时间的酒精暴露方案中才能观察到的。
The long‐term teratogenic effects of prenatal ethanol exposure during the last week of gestation on immune responsiveness and levels of pituitary ACTH and hypothalamic corticotropin‐releasing factor (CRF) were examined in Sprague‐Dawley rats. Immune responsiveness was measured by T‐lymphocyte proliferation in response to mitogenic stimulation with Con A (3 μg/ml) in spleen and thymus cells of 21‐old‐day male refs who were exposed to alcohol in utero. The proliferative response was 8‐fold lower in spleen and twofold lower in thymus cells from alcohol‐exposed animals compared to responses measured in control rats. Thymus weight was significantly smaller at birth in alcohol exposed males, but significantly larger at 21 days of age compared to Controls. Alterations in the content of ACTH and CRF, hormones, known to be direct or indirect modulators of immune responsiveness, were also observed in alcohol exposed males. Hypothalamic Content of CRF and pituitary content of ACTH were significantly lower in alcohol exposed males on postnatal Day 1, but hypothalamic ACTH content was significantly higher compared to controls. These results indicate that alcohol exposure during the last week of gestation can produce alterations of the hypothalamic‐pituitary‐adrenal function in addition to teratogenic effects on the immune system which have been previously observed only with a much longer alcohol exposure regimen