Increased oxidative stress in children exposed to passive smoking
Increased oxidative stress in children exposed to passive smoking
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DOI：
10.1016/j.ijcard.2004.05.069
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发表时间：
2005-04-08
影响因子：
3.5
通讯作者：
Selek, S
中科院分区：
文献类型：
--
作者：
Kosecik, M;Erel, O;Selek, S
背景资料：香烟烟雾中含有多种氧化剂和促氧化剂，能产生自由基，增强氧化应激，从而加速动脉粥样硬化过程。本文对被动吸烟儿童的氧化和抗氧化状态进行了研究，并与非被动吸烟儿童进行了比较。143名9-13岁的学龄儿童，其中61人从未接触过被动吸烟，82人在家中至少在过去一年中每天被动吸烟至少10支。参加了这项研究。测定总抗氧化反应（TAR）以确定血浆的抗氧化状态，并测定总过氧化物浓度以确定血浆的氧化状态。结果：被动吸烟组儿童血浆TAR水平显著低于非被动吸烟组（P=0.018）;平均值（S.D.）值分别为1.49（0.07）和1.52（0.08）mmol Trolox当量/ l，分别。相反，平均值（S.D.）被动吸烟组儿童血浆总过氧化物水平[13.06（2.34）μ mol H2 O2/l]显著高于非被动吸烟组[12.24（1.74）μ mol H2 O2/l]（p=0.015）。平均值（S.D.）被动吸烟儿童的氧化应激指数（OSI）值[0.87（0.15）]显著高于非被动吸烟儿童[0.80（0.10）]（p=0.001）。结论：被动吸烟儿童暴露于氧化应激，氧化应激与动脉粥样硬化等100多种疾病的发病机制有关。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
Background: Atherogenic process is accelerated with cigarette smoke that contains many oxidants and prooxidants, capable of producing free radical and enhancing the oxidative stress. We investigated oxidative and antioxidative status of children who had been exposed to passive smoking and compared with those of not exposed group.Methods: One hundred forty-three school children aged 9-13 years, 61 of whom had never been exposed to passive smoking, and 82 of whom had been exposed to passive smoking at least 10 cigarette per day for at least last I year in their house, were enrolled in this study. Total antioxidative response (TAR) was measured to determine antioxidative status of plasma, and total peroxide concentration was measured to determine oxidative status of plasma. The ratio of TAR to total peroxide was accepted as an indicator of oxidative stress.Results: TAR of plasma was significantly lower in children exposed to passive smoking than in those of not exposed group (p=0.018). Mean (S.D.) values were 1.49 (0.07) and 1.52 (0.08) mmol Trolox Equiv./l, respectively. In contrary, the mean (S.D.) total peroxide level of plasma was significantly higher in children exposed to passive smoking [13.06 (2.34) mu mol H2O2/l] than in not exposed group [12.24 (1.74) mu mol H2O2/l] (p=0.015). The mean (S.D.) oxidative stress index (OSI) value was significantly higher in the children exposed to passive smoking [0.87 (0.15)] than in not exposed group [0.80 (0.10)] (p=0.001).Conclusion: Children who are exposed to passive smoking are exposed to oxidative stress, which has been implicated in the etiopathogenesis of over 100 disorders including atherosclerosis. (c) 2004 Elsevier Ireland Ltd. All rights reserved.