FRIEDEL-CRAFTS REACTION OF INDOLE DERIVATIVES USING THE IMINIUM SALT GENERATED BY THE OXIDATION OF AMINO KETENE SILYL ACETAL
FRIEDEL-CRAFTS REACTION OF INDOLE DERIVATIVES USING THE IMINIUM SALT GENERATED BY THE OXIDATION OF AMINO KETENE SILYL ACETAL
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DOI：
10.3987/com-08-s(f)66
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发表时间：
2009-02-01
期刊：
影响因子：
0.6
通讯作者：
Shimizu, Makoto
中科院分区：
文献类型：
--
作者：
Iwao, Takuya;Shimizu, Makoto
各种吲哚衍生物与氨基烯酮甲硅醇缩醛氧化生成的亚胺盐进行Friedel-Crafts反应，以高产率得到加成产物。引入的甘氨酸部分的加合物与第二亲核试剂的进一步反应提供了双亲核加成产物。
Friedel-Crafts reaction of various indole derivatives proceeded with the iminium salt generated by the oxidation of amino ketene silyl acetal to give the addition products in good yields. Further reaction of the introduced glycine moiety of the adducts with the second nucleophiles provided double nucleophilic addition products.