Developing global maps of insecticide resistance risk to improve vector control.
Developing global maps of insecticide resistance risk to improve vector control.
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DOI：
10.1186/s12936-017-1733-z
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发表时间：
2017-02-21
期刊：
影响因子：
3
通讯作者：
Moyes CL
中科院分区：
文献类型：
--
作者：
Coleman M;Hemingway J;Gleave KA;Wiebe A;Gething PW;Moyes CL
在过去15年中，疟疾传播率大幅下降，少数国家消灭了疟疾，但抗药性和杀虫剂抗药性的增加威胁到了这些成果。对杀虫剂的抗药性降低了最常用的杀虫剂类别-拟除虫菊酯的死亡率，而批准用于公共卫生的替代类别的数量有限。疾病的预防和消灭依赖于对按蚊疟疾病媒的实际控制，这就需要使用有效的杀虫剂。抗药性是一种迅速演变的现象，目前没有资源和人力同时在多个地点连续监测大量蚊子种群。通过联系未发表数据集的作者和保管人，从已发表的文章中获得耐药性数据。在可能的情况下，数据被分解为单个站点和收集期，以提供精细的空间分辨率。目前，该数据集包括1955年至2016年10月来自71个疟疾流行国家和74种按蚊的数据。这包括所有四类杀虫剂和相关抗药性机制的数据。抗药性是一种迅速演变的现象，目前没有资源和人力同时在多个地点连续监测大量蚊子种群。建立了疟疾地图集项目-抗药性增强（MAP-IR），以开发工具，利用现有数据提供杀虫剂抗药性空间分布的最佳估计，并帮助指导关于这一严重问题的控制方案。本文的在线版本（doi：10.1186/s12936-017-1733-z）包含补充材料，可供授权用户使用。
Significant reductions in malaria transmission have been achieved over the last 15 years with elimination occurring in a small number of countries, however, increasing drug and insecticide resistance threatens these gains. Insecticide resistance has decreased the observed mortality to the most commonly used insecticide class, the pyrethroids, and the number of alternative classes approved for use in public health is limited. Disease prevention and elimination relies on operational control of Anopheles malaria vectors, which requires the deployment of effective insecticides. Resistance is a rapidly evolving phenomena and the resources and human capacity to continuously monitor vast numbers of mosquito populations in numerous locations simultaneously are not available. Resistance data are obtained from published articles, by contacting authors and custodians of unpublished data sets. Where possible data is disaggregated to single sites and collection periods to give a fine spatial resolution. Currently the data set includes data from 1955 to October 2016 from 71 malaria endemic countries and 74 anopheline species. This includes data for all four classes of insecticides and associated resistance mechanisms. Resistance is a rapidly evolving phenomena and the resources and human capacity to continuously monitor vast numbers of mosquito populations in numerous locations simultaneously are not available. The Malaria Atlas Project-Insecticide Resistance (MAP-IR) venture has been established to develop tools that will use available data to provide best estimates of the spatial distribution of insecticide resistance and help guide control programmes on this serious issue. The online version of this article (doi:10.1186/s12936-017-1733-z) contains supplementary material, which is available to authorized users.