Place cells and silent cells in the hippocampus of freely-behaving rats
Place cells and silent cells in the hippocampus of freely-behaving rats
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DOI：
10.1523/jneurosci.09-07-02382.1989
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发表时间：
1989-07
影响因子：
2.5
通讯作者：
L. Thompson;PJ Best
中科院分区：
文献类型：
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作者：
L. Thompson;PJ Best
在本研究中，近三分之二的海马锥体细胞在巴比妥类药物麻醉下分离，最大限度地提高了这些细胞的活性，行为沉默。这些“沉默细胞”在清醒的自由行为大鼠中没有自发放电活动。然而，再麻醉和逆向刺激都激活了这些沉默的细胞。从自由行为大鼠中记录到的其余自发活动的海马锥体细胞中，超过92%是定位细胞;即，它们在至少一种环境中表现出放电活动的空间特异性变化。这些位置细胞的放电率根据动物在这种环境中的位置而变化。有趣的是，这些位置细胞中的许多在其他不同的环境中显示出低的或没有自发活动，并且没有空间特异性;即，它们在某些空间环境中缺乏放电，反映了这里报道的更多沉默细胞的行为沉默。在复杂的信息处理过程中，如这里所展示的海马体对空间信息的处理，神经沉默可能是与神经活动一样重要的信号。
In the present study, nearly two-thirds of all hippocampal pyramidal units isolated under barbiturate anesthesia, which maximizes these cell's activity, were behaviorally silent. These “silent cells” showed no spontaneous firing activity in the awake, freely-behaving rat. Both reanesthetization and antidromic stimulation, however, activated these silent cells. More than 92% of the remaining spontaneously active hippocampal pyramidal cells recorded from freely-behaving rats were place cells; i.e., they exhibited spatially specific changes in firing activity in at least one environment. The firing rates of these place cells varied depending on the animal's location in this environment. Interestingly many of these place cells displayed low or no spontaneous activity and no spatial specificity in other, dissimilar environments; i.e., their lack of firing in some spatial environments mirrored the behavioral silence of the more numerous silent cells reported here. In complex information processing, such as the processing of spatial information by the hippocampus demonstrated here, neural silence may be as important a signal as neural activity.