Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond.
Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond.
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DOI：
10.1111/j.1533-869x.2003.01097.x
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发表时间：
2003-09-01
影响因子：
--
通讯作者：
Governor Shri Vishnu Kant Shastri
中科院分区：
文献类型：
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作者：
Halberg, Franz;Cornelissen, Germaine;Governor Shri Vishnu Kant Shastri
我们建议，根据印度文献记载的定时营养素、药物和其他治疗方法的优点，从定时营养素(既是营养素又是药物的物质)中推定出好处，例如用于预防或治疗的抗氧化剂。指出了对一种主要的抗氧化剂褪黑素进行定时的必要性。一项扩大时间放射治疗范围的协议正在等待测试。通过绘制节律和更宽的时间结构进行时间成像，建议使用Keonomes进行早期诊断，例如检测血管疾病风险。对节律和更广泛的时间节律的研究导致了一个动态的功能基因组学，在许多其他变量中，以自由基和抗氧化剂的时间成像为指导。
We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.